Results 71 to 80 of about 433,164 (296)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
High-Efficiency Isolated Photovoltaic Microinverter Using Wide-Band Gap Switches for Standalone and Grid-Tied Applications [PDF]
, 2018 An isolated photovoltaic micro-inverter for standalone and grid-tied applications is designed and implemented to achieve high efficiency. System configuration and design considerations, including the proposed active-clamp forward-flyback resonant ...
Chun-Yu Yang +6 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Deflection and frequency monitoring of the Forth Road Bridge, Scotland, by GPS [PDF]
, 2012 Permission is granted by ICE Publishing to print one copy for personal use. Any other use of these PDF files is subject to reprint fees. Copyright © 2012 Thomas Telford Ltd.The use of carrier phase kinematic GPS (global positioning system) has evolved ...
Atkins, C +5 more
core +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Less is More: Real-time Failure Localization in Power Systems [PDF]
, 2019 Cascading failures in power systems exhibit non-local propagation patterns which make the analysis and mitigation of failures difficult. In this work, we propose a distributed control framework inspired by the recently proposed concepts of unified ...
Guo, Linqi +4 more
core +4 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Parallel AC-Link Connection of Current-Fed Dual Active Bridge Converters
IEEE AccessThis paper proposes a current-fed dual active bridge (DAB) converter, connected in parallel on the secondary-side AC-link, as a DC–DC converter with a high boost ratio and high input current capacity.
Kohjiro Naruse +2 more
doaj +1 more source
Searching for a Connection Between Matroid Theory and String Theory [PDF]
, 2002 We make a number of observations about matter-ghost string phase, which may eventually lead to a formal connection between matroid theory and string theory.
Achucarro +59 more
core +4 more sources