Results 121 to 130 of about 4,734,173 (343)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Deep-learning-based polarization-dependent switching metasurface in dual-band for optical communication

Nanophotonics
To address the critical limitations of conventional band-switching technologies – such as their slow speed, high energy consumption, and mechanical instability – this research introduces a novel deep-learning-driven framework for the intelligent inverse ...
Yan Yihan, Wu Yunkai, Wang Yangwen, Li Jiahao, Hu Jingtian, Wang Xu   +5 more
doaj   +1 more source

Employee Voice and Human Resource Management: An Empirical Analysis using British Data [PDF]

Using British workplace data we examine the relationship between human resource management (HRM) and different forms of employee voice. After controlling for observable establishment characteristics, we find voice and HRM are positively correlated, but ...
Alex Bryson, Paul Willman, Rafael Gomez, Tobias Kretschmer   +3 more
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Dual-resonance optical fiber lossy mode resonance refractive index sensor.

PLoS ONE
In this paper, we propose a dual-channel surface refractive index sensor based on optical fiber lossy mode resonance (LMR). A multilayer transmission matrix model is constructed to simulate and analyze the optical fiber LMR effect based on two ...
Xupeng Wu, Xiaoshuang Dai, Jian Wang, Haipeng Ren, Xu Wang   +4 more
doaj   +1 more source

Automatic Transcranial Sonography-Based Classification of Parkinson’s Disease Using a Novel Dual-Channel CNXV2-DANet

Bioengineering
Transcranial sonography (TCS) has been introduced to assess hyper-echogenicity in the substantia nigra of the midbrain for Parkinson’s disease (PD); however, its subjective and resource-demanding nature has impeded its widespread application.
Hongyu Kang, Xinyi Wang, Yu Sun, Shuai Li, Xin Sun, Fangxian Li, Chao Hou, Sai-kit Lam, Wei Zhang, Yong-ping Zheng   +9 more
doaj   +1 more source

Pricing Decision under Dual-Channel Structure considering Fairness and Free-Riding Behavior

Discrete Dynamics in Nature and Society, 2014
Under dual-channel structure, the free-riding behavior based on different service levels between online channel and offline channel cannot be avoided, which would lead to channel unfairness.
Yongmei Liu, Chunjie Ding, Chen Fan, Xiaohong Chen   +3 more
doaj   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source