Results 91 to 100 of about 1,524,940 (252)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Self-Dual Codes over Commutative Frobenius Rings [PDF]
, 2009 We prove that self-dual codes exist over all finite commutative Frobenius rings, via their decomposition by the Chinese Remainder Theorem into local rings.
Steven T. Dougherty +7 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Self-dual and complementary dual abelian codes over Galois rings [PDF]
, 2019 Self-dual and complementary dual cyclic/abelian codes over finite fields form important classes of linear codes that have been extensively studied due to their rich algebraic structures and wide applications.
San LİNG +3 more
core +1 more source
Self-Dual and LCD Codes from Kneser Graphs K(n, 2) and Generalized Quadrangles
MathematicsIn this paper, we study self-dual and LCD codes constructed from Kneser graphs K(n, 2) and collinearity graphs of generalized quadrangles using the so-called pure and bordered construction. We determine conditions under which these codes are self-dual or
Dean Crnković, Ana Grbac
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Formally self-dual additive codes over F4 [PDF]
, 2010 Additive codes over F4 have been of great interest due to their application to quantum error correction. As another application, we introduce a new class of formally self-dual additive codes over F4, which is a natural analogue of the binary formally ...
Han, Sunghyu +3 more
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source