Results 41 to 50 of about 4,626 (306)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Three-phase double-grounded buck-boost PV inverter without shoot-through problem

Energy Reports, 2023
The conventional transformerless photovoltaic(PV) inverter has the common mode leakage current and shoot-through problems. In addition, the output voltage of the PV module is low under the shading condition, resulting in the inverter not working properly.
Mengwei Yang, Zhilei Yao
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A dual inverter-based supercapacitor direct integration scheme for wind energy conversion systems

, 2013
Interfacing converters used in connecting energy storage systems like supercapacitors and battery banks to wind power systems introduce additional cost and power losses.
Vilathgamuwa, D. Mahinda, Jayasinghe, S. D. Gamini, Madawala, Udaya K., Vilathgamuwa, D. Mahinda., Jayasinghe, S. D. Gamini.   +4 more
core   +1 more source

Development and Control of PMSM Drive With Improved Performance Over Wide Speed and Load Ranges

IEEE Access
Generally, an inverter fed motor drive is often operated under low speed and/or light loads. Hence, except for good driving characteristics, having evenly high efficiencies over wide load range is also critical for a high-performance motor drive.
Yi-Shi Lin, Chen-Wei Yang, Chang-Ming Liaw, Chang-Lin Chiang, Yang-Guang Liu, Chien-Chang Wang   +5 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Analysis and simulation of a novel modulation technique for a dual-output WPT inverter

, 2022
reservedSi è studiato e simulato il funzionamento di un inverter in funzionamento "PIVT". La tecnica utilizza un singolo inverter a “ponte H” a tre gambe per alimentare due bobine con tensioni aventi ampiezze diverse e regolabili indipendentemente ...
DI FRENNA, ALESSANDRO
core  

An extended dual input dual output three level Z source inverter with improved switch loss reduction technique

Journal of Electrical Systems and Information Technology, 2016
Multilevel inverter (MLI) is a proven technology used for industrial applications due to low output total harmonic distortion (THD), high power handling capability and low active device rating.
N.B. Deshmukh, R.D. Thombare, M.M. Waware, D.S. More   +3 more
doaj   +1 more source

Invertible QFTs and differential Anderson duals

, 2023
18 ...
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source