Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
UHGAN: a dual-phase GAN with Hough-transform constraints for accurate farmland road extraction. [PDF]
Wang X, Ma Y.
europepmc +1 more source
Small RNA pathways in mammalian oocytes
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Hydrothermal Conversion of Wastewater Treatment Sands into Dual-Phase FAU/LTA Zeolite: Structural Insights and Performance in Methylene Blue Adsorption. [PDF]
Guaya D, Jara MJ, Cortina JL.
europepmc +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
A stochastic dual-phase-lag two-temperature photo-thermoelastic model for double-porosity semiconductors with initial stress. [PDF]
Rezk EG +6 more
europepmc +1 more source
Carburizing of Dual-Phase Steel
Shin-ichi Kamada +2 more
openaire +2 more sources
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Highly Robust Membrane Electrode Assembly Using Engineered Dual-Phase Iridium Oxide Catalysts Breaking the Activity-Durability Trade-Off in Proton Exchange Membrane Water Electrolysis. [PDF]
Yang HS, Kim SG, Shin R, Cho Y, Pak C.
europepmc +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source

