Results 141 to 150 of about 6,928 (294)
Groundwater parameter estimation by optimization and dual reciprocity
, 2005 A new solution method called the dual reciprocity finite differences method (DRFDM) is proposed. The method combines the finite differences method and optimization technique, and can be implemented in a spreadsheet to solve groundwater parameter estimation problems. In the DRFDM model, the hydraulic heads and transmissivities in the solution domain are
Karahan, H, Ayvaz, MT
openaire +2 more sources
Dual-comb-enhanced microwave clock synchronization over commercial fiber
The large-scale clock network is the key ingredient to obtain high precision in many scenarios, from fundamental research to cutting-edge applications. However, time synchronization among microwave clocks has become an upper limit of the time-frequency ...
Ziyang Chen (3956366) +6 more
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Advanced Robotics Research, EarlyView.This study presents a soft pneumatic fabric bidirectional actuation module (PNEUMA) capable of generating high torque in both bending directions within a single integrated architecture. PNEUMA achieves up to 50 Nm with reduced inflation volume and a lightweight design.
Odysseas Simatos +2 more
wiley +1 more source
, 2010 International audienceThis paper presents a dual reciprocity boundary element model to simulate computationally the distribution of pressure, velocities, temperatures and heat fluxes in two-dimensional control volumes for steady state conditions. Darcy's
Oliveira, Patrícia +2 more
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Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Advanced Science, EarlyView.Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu +13 more
wiley +1 more source
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
Advanced Science, EarlyView.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
Advanced Science, EarlyView.A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang +19 more
wiley +1 more source
The Dual Reciprocity Boundary Element Method (DRBEM) in nonlinear acoustic wave propagation
, 2008 In this paper a novel application of the Boundary Element Method (BEM) to nonlinear acoustic field is presented. The resulting integral equations require the evaluation of a domain integral.
M. H. Aliabadi, MALLARDO, Vincenzo
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