Results 151 to 160 of about 150,972 (303)

The impact of sensory impairment on cardiometabolic multimorbidity in middle-aged and older adults: the mediating role of depressive symptoms

European Journal of Medical Research
Background Sensory impairment has imposed a great burden on public health, particularly among middle-aged and older adults. Individuals with dual sensory impairment (DSI) often experience multiple chronic conditions.
Yunteng Fang, Junqiu Zhao, Haoxiang Xu, Jiayi Shen, Xingwei Wei, Qiwen Huang, Wuming Hu, Lingchun Lv   +7 more
doaj   +1 more source

Hearing, Vision, or Dual Sensory Impairment and Dementia Risk [PDF]

JAMA Network Open, 2021
openaire   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Association between sensory impairment and cardiometabolic multimorbidity among older Chinese adults: a cross-sectional study based on the China Health and Retirement Longitudinal Study

BMC Geriatrics
Background Sensory impairments and cardiometabolic multimorbidity (CMM) are prevalent age-related conditions that significantly impact the health of older adults.
Jing Xi, Kewen Niu, Jiaqi Xu, Yangyang Lu, Xinjie Li, Hongyan Meng, Chun Li   +6 more
doaj   +1 more source

An athletic approach to studying perception-action integration: Does sport-specific training, and the impact of injury, influence how individuals visually guide navigation? [PDF]

, 2015
The objective of this thesis was to investigate perception-action integration capabilities of individuals during a choice navigation task. This task assessed navigation strategies in open space while individuals avoided colliding with two vertical ...
Baker, Carmen, Campos, Jennifer, Ph.D, Cinelli, Michael E, Ph.D.   +2 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Longitudinal associations between cardiovascular-kidney-metabolic syndrome and sensory impairments in Chinese middle-aged and older adults: a weighted marginal structural model analysis

BMC Public Health
Background Sensory impairments significantly contribute to functional decline in aging populations, yet their relationship with the newly defined cardiovascular-kidney-metabolic (CKM) syndrome remains poorly understood.
Qi Zhang, Jianlin Lin, Shaofeng Zhou, Xinglin Ruan, Jing Wu, Shiwei Ruan   +5 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Structural validity of Balance Evaluation Systems Test assessed usingfactor and Rasch analyses in patients with stroke [PDF]

, 2019
学位記番号 ...
Miyata, Kazuhiro, ミヤタ, カズヒロ, 宮田, 一弘   +2 more
core