Results 151 to 160 of about 311,557 (292)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

An investigation into possible interactions in the vestibular system and the cochlea during electrical stimulation

Frontiers in Neuroscience
IntroductionThe vestibular system is crucial for balance, spatial orientation, and gaze stabilization. Bilateral vestibulopathy (BV) severely impairs these functions, often co-occurring with severe to profound hearing loss.
David Lanthaler, Andreas Griessner, Viktor Steixner, Julie Corre, Maurizio Ranieri, Samuel Cavuscens, Gautier Grouvel, Nils Guinand, Clemens M. Zierhofer, Angélica Pérez Fornos   +9 more
doaj   +1 more source

Research issues in implementing remote presence in teleoperator control [PDF]

, 1981
The concept of remote presence in telemanipulation is presented. A conceptual design of a prototype teleoperator system incorporating remote presence is described. The design is presented in functional terms, sensor, display, and control subsystem.
Corker, K., Lyman, J., Mishkin, A. H.
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Promoting and maintaining health of people with sight loss: A scoping study [PDF]

, 2009
This study was undertaken in response to a request by the Thomas Pocklington Trust to identify and explore the following issues: • The needs and concerns regarding immediate risks to health and safety related to sight loss; • Additional risks arising ...
Cattan, M, Hughes, S, Kime, NH, Purcell, M, Woodward, J   +4 more
core  

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Effects of Labeling and Consumer Health Trends on Preferred Ground Beef Color Characteristics, Fat Content and Palatability in Simulated Retail Display [PDF]

, 2017
Nutritional concerns have impacted the protein market, decreasing red meat consumption as well as prompting the advent of lean and extra lean ground beef. However, such lean blends of ground beef may suffer in palatability. This study seeks to bridge the
Anthony, Nicholas B., Pohlman, Fred, Pohlman, Fred W., II, Yang, Famous   +3 more
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Proposed Long Short-Term Memory Model Utilizing Multiple Strands for Enhanced Forecasting and Classification of Sensory Measurements

Mathematics
This paper presents a new deep learning model called the stranded Long Short-Term Memory. The model utilizes arbitrary LSTM recurrent neural networks of variable cell depths organized in classes. The proposed model can adapt to classifying emergencies at
Sotirios Kontogiannis, George Kokkonis, Christos Pikridas   +2 more
doaj   +1 more source