Results 51 to 60 of about 542,850 (297)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Target Detection Algorithm Based on Global Feature Fusion in Parallel Dual Path Backbone [PDF]

Jisuanji kexue yu tansuo
The active downsampling of the backbone of conventional single path architecture often leads to insufficient feature extraction and information loss.
QIU Yunfei, XIN Hao
doaj   +1 more source

CDAM-Net: Channel shuffle dual attention based multi-scale CNN for efficient glaucoma detection using fundus images [PDF]

Glaucoma is a typical eye disorder that induces damage to the optic nerve due to increased intraocular pressure. It ultimately leads to partial or complete blindness without clinical reversal.
Das, Dipankar, Bhandary, Sulatha V., Acharya, U. Rajendra, Nayak, Deepak Ranjan   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Scale effects, time-varying markups, and the cyclical behaviour of primal and dual productivity [PDF]

This paper presents estimates of the degree of returns to scale using nonparametric measures of primal and dual productivity for 2-digit US manufacturing industries. As part of the analysis, the cyclical behaviour of primal and dual productivity measures
Alpay Filiztekin, Sumru Altug
core   +1 more source

Dual-carrier Floquet circulator with time-modulated optical resonators [PDF]

, 2017
Spatio-temporal modulation has shown great promise as a strong time-reversal symmetry breaking mechanism that enables integrated nonreciprocal devices and topological materials at optical frequencies.
Zheng Wang (25883), S. Hossein Mousavi (1653739), Ian A. D. Williamson (6060725)   +2 more
core   +1 more source

Queue-Aware Cell Activation and User Association for Traffic Offloading via Dual-Connectivity

IEEE Access, 2019
With the objective of reducing energy cost, we study the stochastic optimization of traffic off-loading via dual-connectivity by joint cell activation and user association.
Qiaoni Han, Bo Yang, Xiaocheng Wang
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source