Results 41 to 50 of about 2,097 (305)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Multi-cell downlink coordinated beam forming algorithm based on fairness duality theory
Tongxin xuebao, 2013 With the goal to optimize the multi-cell downlink beamforming based on the criterion of the worst-user rate maximization,the Lagrangian duality theory was first used to derive a virtual multi-cell uplink optimization problem that was dual to the primal ...
Shi-wen HE, Yong-ming HUANG, Lv-xi YANG
doaj +2 more sources
Linear programming with inequality constraints via entropic perturbation
International Journal of Mathematics and Mathematical Sciences, 1996 A dual convex programming approach to solving linear programs with inequality constraints through entropic perturbation is derived. The amount of perturbation required depends on the desired accuracy of the optimum.
H.-S. Jacob Tsao, Shu-Cherng Fang
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Complete Solutions to General Box-Constrained Global Optimization Problems
Journal of Applied Mathematics, 2011 This paper presents a global optimization method for solving general nonlinear programming problems subjected to box constraints. Regardless of convexity or nonconvexity, by introducing a differential flow on the dual feasible space, a set of complete ...
Dan Wu, Youlin Shang
doaj +1 more source
N-K Constrained Composite Generation and Transmission Expansion Planning With Interval Load
IEEE Access, 2017 The uncertainties of the predicted load demand and N-K contingencies are very significant aspects to composite generation and transmission expansion planning (CGTEP).
Shaoyun Hong +2 more
doaj +1 more source
An optimal two-stage distribution of material flow at the fuel and energy complex enterprises [PDF]
E3S Web of Conferences, 2019 The two-stage distributing of material flows in the transport-logistics system of fuel and energy complex is considered. The structural elements of such system are mines (centers of the first stage), extracting coal from various mineral deposits in a ...
Blyuss Borys +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
On duality theory for multiobjective semi-infinite fractional optimization model using higher order convexity [PDF]
, 2021 Tamanna Yadav, S. K. Gupta
openalex +1 more source