Results 91 to 100 of about 940,969 (360)

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

New England Journal of Medicine, 2018
BACKGROUND Patisiran, an investigational RNA interference therapeutic agent, specifically inhibits hepatic synthesis of transthyretin. METHODS In this phase 3 trial, we randomly assigned patients with hereditary transthyretin amyloidosis with ...
D. Adams, A. González-Duarte, W. O'Riordan, Chih-Chao Yang, M. Ueda, A. Kristen, I. Tournev, H. Schmidt, T. Coelho, J. Berk, Kon-Ping Lin, G. Vita, S. Attarian, V. Planté-Bordeneuve, M. Mezei, J. Campistol, J. Buades, T. Brannagan, Byoung-Joon Kim, Jeeyoung Oh, Y. Parman, Y. Sekijima, P. Hawkins, S. Solomon, M. Polydefkis, P. Dyck, P. Gandhi, S. Goyal, Jihong Chen, A. Strahs, S. Nochur, M. Sweetser, P. Garg, A. Vaishnaw, J. Gollob, O. Suhr   +35 more
semanticscholar   +1 more source

Prospective validation of podoplanin expression as a diagnostic biomarker of acute promyelocytic leukemia

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Acute promyelocytic leukemia (APL) is a medical emergency that needs immediate diagnosis and treatment. Podoplanin, a transmembrane glycoprotein that binds CLEC‐2 on platelets, was recently demonstrated to be abnormally expressed in leukemic blasts in APL, as opposed to other forms of AML, in a study using thawed primary cells.
Camilla Maria de Alencar Saraiva, Carla Roberta Peachazepi Moraes, Bruno Kosa Lino Duarte, Gislaine Borba Oliveira, Herton Luiz Alves Sales Filho, Paula de Melo Campos, Sara Teresinha Olalla Saad, Erich Vinicius De Paula   +7 more
wiley   +1 more source

Eribulin Synergistically Increases Anti-Tumor Activity of an mTOR Inhibitor by Inhibiting pAKT/pS6K/pS6 in Triple Negative Breast Cancer

Cells, 2019
Unlike other breast cancer subtypes, patients with triple negative breast cancer (TNBC) have poor outcomes and no effective targeted therapies, leaving an unmet need for therapeutic targets. Efforts to profile these tumors have revealed the PI3K/AKT/mTOR
Wei Wen, Emily Marcinkowski, David Luyimbazi, Thehang Luu, Quanhua Xing, Jin Yan, Yujun Wang, Jun Wu, Yuming Guo, Dylan Tully, Ernest S. Han, Susan E. Yost, Yuan Yuan, John H. Yim   +13 more
doaj   +1 more source

A Pilot Randomized Controlled Trial of Eye Movement Desensitization and Reprocessing Therapy for Adults With Binge‐Eating Disorder

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Binge‐eating disorder (BED) is a serious psychological condition, often associated with trauma, as well as many critical physical and psychological consequences. Despite the availability of several evidence‐based treatments, full remission rates and long‐term recovery rates remain suboptimal.
Amaani H. Hatoum, Katie Richard, Amy L. Burton, Elizabeth Rieger, Stephen Touyz, Maree J. Abbott   +5 more
wiley   +1 more source

Predicting oxygen thresholds of marine taxa to improve ecological forecasts

Ecography, EarlyView.
Species' ranges are shifting in response to increasing temperature and decreasing oxygen in coastal oceans. Predicting these shifts is limited by information on physiological oxygen thresholds and how they depend on temperature. Here we collate laboratory‐derived measurements of a common oxygen threshold, pcrit, for 148 animal species that span six ...
Timothy E. Essington, James T. Thorson, Curtis Deutsch   +2 more
wiley   +1 more source

Oxaliplatin but Not Irinotecan Impairs Posthepatectomy Liver Regeneration in a Murine Model

International Journal of Hepatology, 2011
Introduction. We examined the murine hepatectomy model of liver regeneration (LR) in the setting of neoadjuvant chemotherapy. Methods. C57BL/6 mice were randomized to receive neoadjuvant intraperitoneal (IP) injections of a control, oxaliplatin (15 mg/kg)
Perry A. Soriano, Nian Liu, Erick Castillo, Brock Foster, Avo Artinyan, Joseph Kim, Wendong Huang, Lawrence D. Wagman   +7 more
doaj   +1 more source

Constância Lima Duarte

Jangada: crítica | literatura | artes, 2020
Não apresenta.
openaire   +2 more sources

Privileging Micro over Macro? A History of Conflicting Positions [PDF]

Mainstream macroeconomists agree that we live in the age of microfoundations. The recent worldwide financial crisis may have emboldened critics of this microfoundational orthodoxy, but it remains the dominant view that macroeconomic models must go beyond
Gilberto Tadeu Lima, Pedro Garcia Duarte
core  

Volumetric MRI study of the brain in patients with neurocysticercosis and mesial temporal lobe epilepsy

Epileptic Disorders, EarlyView.
Abstract Objective Neurocysticercosis (NCC) is a common parasitic infection of the central nervous system and a known cause of focal epilepsy. Its potential role in triggering or contributing to mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is suggested, but the impact on brain volumetry remains unclear.
Jaisa Quedi Araújo, Bruna da Silveira Arruda, Sandra Polita, Maurício Anés, Thiago Junqueira Ribeiro de Rezende, Matheus de Lima Ruffini, Adolfo Moraes de Souza, Jordana Soares Chaves, Fabiano Reis, Marino Muxfeldt Bianchin, Juliana Ávila Duarte   +10 more
wiley   +1 more source

Regulation of Endotheliopathy by Chromatin-associated Long Noncoding RNA

JVS - Vascular Science, 2023
Zhen B. Chen, Xiaofang Tang, Kiran Sriram, Yingjun Luo, Dongqiang Yuan, Naseeb Kaur Malhi, Xuejing Liu, Rama Natarajan   +7 more
doaj   +1 more source