Results 51 to 60 of about 11,793 (291)

Deubiquitylating enzymes and their emerging role in plant biology

Frontiers in Plant Science, 2014
Ubiquitylation is a reversible post-translational modification that is involved in various cellular pathways and that thereby regulates various aspects of plant biology. For a long time, functional studies of ubiquity lion have focused on the function of
Erika eIsono, Marie-Kristin eNagel
doaj   +1 more source

Unveil Fundamental Graph Properties for Neural Architecture Search

Advanced Science, EarlyView.
This paper proposes NASGraph, a graph‐based framework that represents neural architectures as graphs whose structural properties determine performance. By revealing structure–performance relationships, NASGraph enables efficient neural architecture search with significantly reduced computation.
Zhenhan Huang, Tejaswini Pedapati, Pin‐Yu Chen, Chunheng Jiang, Jianxi Gao   +4 more
wiley   +1 more source

Hip sonography in Hungary [PDF]

Exploration of Musculoskeletal Diseases
The diagnosis of hip dysplasia has developed very differently in different countries over the last few decades. The development and current situation in Hungary is described in this paper.
Beat Dubs
doaj   +1 more source

DUBs, Hypoxia, and Cancer

Trends in Cancer, 2019
Alterations in protein ubiquitylation and hypoxia are commonly associated with cancer. Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be opposed by deubiquitinases (DUBs), which have emerged as promising drug targets.
Mennerich, D. (Daniela), Kubaichuk, K. (Kateryna), Kietzmann, T. (Thomas)   +2 more
openaire   +3 more sources

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Hochschuldidaktik. Ein programmatischer Beitrag aufgrund langer Erfahrung

Beiträge zur Lehrerinnen- und Lehrerbildung, 2009
Leider ist die hochschuldidaktische Forschung in den deutschsprachigen Ländern immer noch zu wenig entwickelt. Hingegen bemühen sich immer mehr Hochschulen und Verbünde um einen gezielten Aufbau der hochschuldidaktischen Kurse.
Rolf Dubs
doaj   +1 more source

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source

Die Führung einer Schule

Beiträge zur Lehrerinnen- und Lehrerbildung, 1992
Der Autor, Gründer und Leiter des Instituts für Wirtschaftspädagogik und derzeit Rektor der Hochschule St. Gallen, räumt der Schule zwar eine Eigengesetzlichkeit ein, vertritt und belegt in diesem Artikel jedoch die Auffassung, dass eine zeitgemässe ...
Rolf Dubs
doaj   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, EarlyView.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources