Results 31 to 40 of about 66,813 (317)

Safety and immunogenicity of mRNA COVID‐19 vaccine in inpatients with muscular dystrophy

Muscle &Nerve, Volume 67, Issue 2, Page 117-123, February 2023., 2023
Abstract Introduction/Aims Due to muscular weakness and cardiopulmonary dysfunction, patients with muscular dystrophy (MD) have an increased risk of serious complications from coronavirus disease‐2019 (COVID‐19). Although vaccination is recommended, COVID‐19 vaccination safety and immunogenicity in these patients are unknown.
Tomoko Saito, Toshio Saito, Hiroya Hashimoto, Katsuhisa Ogata, Michio Kobayashi, Hiroto Takada, Satoshi Kuru, Takashi Kimura, Akinori Nakamura, Tsuyoshi Matsumura   +9 more
wiley   +1 more source

Duchenne muscular dystrophy [PDF]

BMJ Case Reports, 2014
A 15-year-old boy presented with progressive proximal weakness of the lower limbs starting at 4 years of age followed by involvement of the upper limbs. He is the product of a consanguineous marriage; he had a family history of similar disease in a second-degree cousin and also had a history of delayed motor developmental milestones since birth ...
Rajeev Chauhan, Velu Nair, Vineet Behera, Manas Kumar Behera   +3 more
openaire   +5 more sources

Measuring carer quality of life in Duchenne muscular dystrophy: a systematic review of the reliability and validity of self-report instruments using COSMIN

Health and Quality of Life Outcomes, 2022
Introduction Duchenne muscular dystrophy is a rare, progressive, life-limiting genetic neuromuscular condition that significantly impacts the quality of life of informal caregivers. Carer quality of life is measured using heterogeneous self-report scales,
Jill Carlton, Philip A. Powell, Project HERCULES Carer Group   +2 more
doaj   +1 more source

Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis

European Journal of Epidemiology, 2020
Several studies indicate that prognosis for survival in Duchenne muscular dystrophy (DMD) has improved in recent decades. However, published evidence is inconclusive and some estimates may be obsolete due to improvements in standards of care, in ...
E. Landfeldt, R. Thompson, T. Sejersen, H. McMillan, J. Kirschner, H. Lochmüller   +5 more
semanticscholar   +1 more source

Beyond MeSH: Fine-Grained Semantic Indexing of Biomedical Literature based on Weak Supervision [PDF]

Information Processing and Management 57 (2020) 102282, 2020
In this work, we propose a method for the automated refinement of subject annotations in biomedical literature at the level of concepts. Semantic indexing and search of biomedical articles in MEDLINE/PubMed are based on semantic subject annotations with MeSH descriptors that may correspond to several related but distinct biomedical concepts.
arxiv   +1 more source

Exhibition: Duchenne and Gachet [PDF]

BMJ, 1999
“Duchenne de Boulogne: la mecanique des passions” is at the Ecole nationale superieure des Beaux-arts, Paris, until 4 April, and “Un ami de Cezanne et Van Gogh: le docteur Gachet” is at the Grand Palais, Paris, until 26 April Guillaume Duchenne, born in Boulogne in 1807, studied medicine in Paris and came under the spell of Laennec, Dupuytren, and ...
openaire   +3 more sources

Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy

Neurology, 2020
Objective To report safety, pharmacokinetics, exon 53 skipping, and dystrophin expression in golodirsen-treated patients with Duchenne muscular dystrophy (DMD) amenable to exon 53 skipping.
D. Frank, F. Schnell, Cody Akana, Saleh H. El-Husayni, C. Desjardins, J. Morgan, J. Charleston, V. Sardone, J. Domingos, G. Dickson, V. Straub, M. Guglieri, E. Mercuri, L. Servais, F. Muntoni   +14 more
semanticscholar   +1 more source

Early detection of left ventricular involvement in patients with Duchenne’s and Becker’s muscular dystrophy

Al-Azhar Assiut Medical Journal, 2019
Background Patients with Duchenne muscular dystrophy (DMD) and Becker’s muscular dystrophy (BMD) may have asymptomatic cardiac involvement for years before the development of dilated cardiomyopathy and even showed normal conventional echocardiographic ...
Shaimaa A Habib, Mohie El Din T Mohamed
doaj   +1 more source

Proteomic profiling of impaired excitation–contraction coupling and abnormal calcium handling in muscular dystrophy

PROTEOMICS, Volume 22, Issue 23-24, December 2022., 2022
Abstract The X‐linked inherited neuromuscular disorder Duchenne muscular dystrophy is characterised by primary abnormalities in the membrane cytoskeletal component dystrophin. The almost complete absence of the Dp427‐M isoform of dystrophin in skeletal muscles renders contractile fibres more susceptible to progressive degeneration and a leaky ...
Paul Dowling, Stephen Gargan, Dieter Swandulla, Kay Ohlendieck   +3 more
wiley   +1 more source

Repurposing Dantrolene for Long-Term Combination Therapy to Potentiate Antisense-Mediated DMD Exon Skipping in the mdx Mouse

Molecular Therapy: Nucleic Acids, 2018
Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, resulting in loss of dystrophin, which is essential to muscle health. DMD “exon skipping” uses anti-sense oligo-nucleotides (AONs) to force specific exon exclusion during mRNA processing to
Derek W. Wang, Ekaterina I. Mokhonova, Genevieve C. Kendall, Diana Becerra, Yalda B. Naeini, Rita M. Cantor, Melissa J. Spencer, Stanley F. Nelson, M. Carrie Miceli   +8 more
doaj   +1 more source