Results 31 to 40 of about 114,439 (345)
Dystrophic Skeletal Muscle Phenotypes Can Be Horizontally Transferred via Fecal Microbiome Transplantations. [PDF]
FASEB JWe sought to determine a causal role for the microbiota in promoting dystrophic muscle characteristics by performing intra/inter‐genotype fecal microbiota transplantations (FMT) between wildtype (C57BL/10) and mdx (C57BL/10ScSn‐Dmdmdx/J) mice. We found that transplantation of mdx microbiotas into a wildtype mouse induced an mdx‐like muscle phenotype ...
Butcher J +5 more
europepmc +2 more sources
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy
JAMA Network Open, 2022 This nonrandomized controlled trial examines efficacy of vamorolone treatment for Duchenne muscular dystrophy among boys compared with glucocorticoid treatment.
J. Mah +26 more
semanticscholar +1 more source
Global epidemiology of Duchenne muscular dystrophy: an updated systematic review and meta-analysis
Orphanet Journal of Rare Diseases, 2020 Background Duchenne Muscular Dystrophy (DMD) is a rare disorder caused by mutations in the dystrophin gene. A recent systematic review and meta-analysis of global DMD epidemiology is not available.
S. Crisafulli +5 more
semanticscholar +1 more source
Quantitative immuno-mass spectrometry imaging of skeletal muscle dystrophin
Scientific Reports, 2021 Emerging and promising therapeutic interventions for Duchenne muscular dystrophy (DMD) are confounded by the challenges of quantifying dystrophin. Current approaches have poor precision, require large amounts of tissue, and are difficult to standardize ...
David P. Bishop +10 more
doaj +1 more source
Frontiers in Genetics, 2023 Muscle damage and fibro-fatty replacement of skeletal muscles is a main pathologic feature of Duchenne muscular dystrophy (DMD) with more proximal muscles affected earlier and more distal affected later in the disease course, suggesting that different ...
Shirley Nieves-Rodriguez +19 more
doaj +1 more source
CRISPR Therapeutics for Duchenne Muscular Dystrophy
International Journal of Molecular Sciences, 2022 Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disorder with a prevalence of approximately 1 in 3500–5000 males. DMD manifests as childhood-onset muscle degeneration, followed by loss of ambulation, cardiomyopathy, and death in ...
Esra Erkut, T. Yokota
semanticscholar +1 more source
Frontiers in Psychology, 2023 IntroductionHuman cooperativeness is an important personality trait. However, the mechanism through which people cooperate remains unclear. Previous research suggests that one of the proposed functions of smiling is to advertise altruistic dispositions ...
Xiaoqi Deng +3 more
doaj +1 more source
Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]
, 2013 Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core +3 more sources
Muscle and Nerve, 2021 Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene resulting in the absence of dystrophin. Casimersen is a phosphorodiamidate morpholino oligomer designed to bypass frameshift DMD mutations and produce internally truncated, yet ...
K. Wagner +6 more
semanticscholar +1 more source