Results 201 to 210 of about 83,778 (352)

Corrosion Casting, a Known Technique for the Study and Teaching of Vascular and Duct Structure in Anatomy [PDF]

open access: diamond, 2017
Roberto Javier Rueda‐Esteban   +3 more
openalex   +1 more source

Tumor‐Derived Interleukin 35 Promotes Fibrosis in the Tumor Microenvironment of Pancreatic Cancer by Activating Pancreatic Stellate Cells

open access: yesAdvanced Science, EarlyView.
This study demonstrates that tumor‐derived IL‐35 promotes pancreatic cancer fibrosis by indirectly activating pancreatic stellate cells through IGFBP2/IGF‐1R/PI3K‐Akt and Tsp‐1/TGF‐β pathways. IL‐35 blockade reduces stromal fibrosis, restores chemosensitivity, and synergizes with gemcitabine‐based regimens, highlighting IL‐35 as a promising therapeutic
Hui Li   +14 more
wiley   +1 more source

Mapping the Tissue‐of‐Origins of Mesenchymal Stromal Cells in Injury Repair

open access: yesAdvanced Science, EarlyView.
This study maps mesenchymal stromal cells (MSCs) across multiple tissues, revealing that bone marrow–derived MSCs mobilize monocytes via CCL2 to promote systemic inflammation but do not migrate to distant organs to form fibrotic or tumor stroma. Instead, local MSCs dominate tissue remodeling, suggesting a “two‐hit” model linking systemic inflammation ...
Xinyu Thomas Tang   +4 more
wiley   +1 more source

Role of the EUS in the Treatment of Biliopancreatic Disease in Patients with Surgically Altered Anatomy. [PDF]

open access: yesDiagnostics (Basel)
Cintolo M   +10 more
europepmc   +1 more source

Targeting Mast Cell Activation and MIF‐Mediated Remodelling Enhances Chemotherapy Response in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Neoadjuvant gemcitabine plus nab‐paclitaxel (AG) reprograms pancreatic ductal adenocarcinoma by shifting malignant cells toward a classical phenotype and remodeling the tumor microenvironment. Despite enhancing cytotoxic NKT cells, AG activates tumor‐associated mast cells (TAMCs) and inflammatory CAFs through MIF signaling.
Libo Wang   +16 more
wiley   +1 more source

Common bile duct morphology is associated with recurrence of common bile duct stones in Billroth II anatomy patients

open access: diamond, 2021
Xu Ji   +9 more
openalex   +1 more source

Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium

open access: yesAdvanced Science, EarlyView.
Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion, followed by delayed invasion with matrix reorganization and proliferation.
Kabilan Sakthivel   +8 more
wiley   +1 more source

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