Results 251 to 260 of about 776,755 (348)

Transgastric ERCP is a Useful Modality for Addressing Biliary Complications in Patients After Orthotopic Liver Transplantation and History of Roux-en-Y Gastric Bypass: Case Report and Proposed Treatment Algorithm. [PDF]

Clin Case Rep
Haynes N, Archie W, Baimas-George M, Peterson K, Casingal V, Levi D, Eskind L, Soto J, Vrochides D.   +8 more
europepmc   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Gallbladder agenesis leading to an unnecessary surgery: a case report. [PDF]

Front Med (Lausanne)
Yin Z, Liu Y.
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

A dual-lobe strategy in living-donor liver transplantation: overcoming small-for-size graft limitations in an obese patient: a case report. [PDF]

Clin Transplant Res
Sahoo BS, Makki K, Yadav Y, Karan T, Srivastava P, Vij V.   +5 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Ejaculatory duct cyst mimicking post-TURP ejaculatory dysfunction: A diagnostic challenge in a patient with hemospermia and hypospermia. [PDF]

Urol Case Rep
Maachi Y, Bentalb Y, Zaki A, Slaoui A, Karmouni T, Koutani A, Elkhader K.   +6 more
europepmc   +1 more source

Catechol Derivative‐Based Bioadhesives: Molecular Design for Precision Medical Adhesion

Advanced Science, EarlyView.
This study utilizes tree‐inspired side‐chain engineering to graft five catechol derivatives onto PVA, systematically revealing how side‐chain length and substituents regulate adhesion and cohesion properties. Among them, the PVA‐CA patch demonstrates superior tissue adhesion, biocompatibility, and promotes regeneration, establishing a programmable ...
Xueyu Wang, Zixin Yang, Shan Wang, Weiwei Tan, Zhirui He, Qinyu Duan, Huanan Wang, Tao Chen, Shanshan Hu   +8 more
wiley   +1 more source

Difficult bile-duct stones in surgical anatomy managed with entero-endoscopic retrograde cholangiopancreatography and a new slim cholangioscope. [PDF]

Endoscopy
Spadaccini M, Terrin M, De Marco A, Marcozzi G, Colombo M, Fugazza A, Repici A.   +6 more
europepmc   +1 more source

Open transabdominal cisterna chyli ligation for refractory chylothorax: a retrospective case series. [PDF]

BMC Surg
Çetinkaya Ç, Batırel HF.
europepmc   +1 more source