Results 111 to 120 of about 168,901 (301)

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source

Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast [PDF]

, 2006
We investigated the expression of membrane type-1 (MT1)-MMP, MMP2, MMP9 and TIMP2 mRNAs and their roles in ductal carcinoma in situ (DCIS) and T1 and T2 invasive ductal carcinoma of the breast.
Black, Brummer, Byeong Woo Park, Chan-il Park, Curran, Duffy, Elston, Gilles, Hee Jung Kim, Hy-de Lee, Ishigaki, Joensuu, Jones, Kainz, Kaufmann, Kodate, Liabakk, Liotta, Lyzak, Massi, Mulder, Nakanishi, Nielsen, Pacheo, Polette, Pyke, Rha, Ristamaki, Sato, Schneider, Scorilas, Talvensaari-Mattila, Talvensaari-Mattila, Toi, Ueno, Uhl-Steidl, Woo Hee Jung, Yu   +37 more
core   +2 more sources

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

Basal cytokeratin as a potential marker of low risk of invasion in ductal carcinoma in situ

Clinics, 2013
OBJECTIVES: Biological markers that predict the development of invasive breast cancer are needed to improve personalized therapy for patients diagnosed with ductal carcinoma in situ.
Fernando N. Aguiar, Henrique N. Mendes, Cinthya S. Cirqueira, Carlos E. Bacchi, Filomena M. Carvalho   +4 more
doaj  

Breast cancer or metastasis? An unusual case of metastatic malignant pleural mesothelioma to the breast [PDF]

, 2015
Background: Metastases to the breast from extramammary malignancies are very rare, and ruling out the diagnosis of primary breast tumor is important in order to decide on clinical management and predict prognosis.
Derme, Martina, FRAMARINO DEI MALATESTA, Marialuisa, Iannini, Isabella, Masselli, Gabriele, Pecorella, Irene, Sammartino, Paolo   +5 more
core   +2 more sources

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

Advanced Science, EarlyView.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen, Saibo Ma, Hao Wu, Lingna Zheng, Yunpeng Yi, Guangnian Liu, Baoyi Li, Jiayi Sun, Yang Du, Bing Wang, Yike Liu, Cheng Zhang, Jing Chang, Yuheng Pang, Wenjing Wang, Meng Wang, Motao Zhu   +16 more
wiley   +1 more source

Invasive ductal carcinoma ex pleomorphic adenoma of the lacrimal gland - a long term follow-up case

Human Pathology: Case Reports, 2017
We experienced a case of malignant orbital tumor in a 72-year-old Japanese man. He noticed protrusion of his left eye, and received resection of the left orbital tumor.
Naoko Nambu, Yoshitane Tsukamoto, Hiromi Tsuji, Takahiro Watanabe, Ryohei Shigehara, Masao Kakibuchi, Eiichi Morii, Seiichi Hirota   +7 more
doaj  

Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial [PDF]

, 2014
© Cuzick et al. Open Access article distributed under the terms of CC BY.http://dx.doi.org/10.1016/S1470-2045(14)71171-
Abdi, E, Anderson, E, Atkinson, C, Baum, M, Beith, J, Bird, A, Birrell, S, Blamey, R, Blum, R, Boyages, J, Buser, K, Campbell, I, Cawthorn, S, Cawthorne, Simon, Chapman, C, Chipman, M, Coates, A, Collins, J P, Craft, P, Cuzick, J, Denton, L, Dewar, J, Dowsett, M, Earl, H, Eccles, D, Edwards, R, Evans, G, Fallowfield, L, Fentiman, I, Forbes, J F, Forbes, John F, Friedlander, M, Garcia, J, Gebski, V, George, W, Gilbert, F J, Godbolt, P, Goldhirsch, A, Hamed, H, Hanby, A, Hart, S, Hearne, J, Henry, A, Hirst, C, Holcombe, C, Holli, Kaija, Howell, A, Kealy, R, Kirk, J, Lansdown, M, Lee, M, Lennard, T, Lindsay, D, MacKay, J, MacMichael, K, MacNeil, F, Maddox, P, Mansel, R, McAleese, P, Melmeth, A, Mitine, C, Newton, A, Normand, C, Odling-Smee, W, Oivanen, T, Pagani, O, Paksec, L, Powles, T, Raytor, Z, Richmond, B, Robertson, J, Sainsbury, R, Sauven, P, Seccombe, M, Sestak, Ivana, Simes, R J, Stewart, R, Stotter, A, Thompson, A, Thornto, R, Toy, J, Twentyman, P, Underhill, C, Vergine, Beata, Ward, R, White, S, Wilkinson, A, Wilkinson, S, Williamson, J, Wynne, C   +89 more
core   +2 more sources

Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Advanced Science, EarlyView.
This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick Walter, Mohsen Akbari   +8 more
wiley   +1 more source

Recurrent Invasive Ductal Breast Carcinoma Presenting as Primary Adrenal Insufficiency with Adrenal Crisis

AACE Clinical Case Reports, 2020
: Objective: We report the first case of recurrent ductal breast carcinoma presenting as primary adrenal insufficiency. Methods: We describe a patient who developed a recurrence of invasive ductal breast carcinoma which went undetected until the patient
Mitha Madhava Naik, MD, Michael James Nestasie, DO, Murray B. Gordon, MD, FACE   +2 more
doaj