Results 81 to 90 of about 1,818,460 (375)

Independent predictors of breast malignancy in screen-detected microcalcifications: biopsy results in 2545 cases [PDF]

, 2011
Background: Mammographic microcalcifications are associated with many benign lesions, ductal carcinoma in situ (DCIS) and invasive cancer. Careful assessment criteria are required to minimise benign biopsies while optimising cancer diagnosis.
Downey, P., Farshid, G., Gill, P., Pieterse, S., Sullivan, T.   +4 more
core   +2 more sources

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Consultoria em patologia cirúrgica mamária: variabilidade interobservador no diagnóstico de lesões proliferativas intraductais atípicas Consultation in breast surgical pathology: interobserver diagnostic variability of atypical intraductal proliferative lesions

Revista Brasileira de Ginecologia e Obstetrícia, 2013
OBJETIVO: Avaliar a concordância nos diagnósticos histopatológicos de lesões mamárias proliferativas intraductais entre patologistas gerais e especialistas em patologia mamária.
Amanda Arantes Perez, Débora Balabram, Marcio de Almeida Salles, Helenice Gobbi   +3 more
doaj  

Macrophages promote the progression of premalignant mammary lesions to invasive cancer. [PDF]

, 2017
Breast cancer initiation, progression and metastasis rely on a complex interplay between tumor cells and their surrounding microenvironment. Infiltrating immune cells, including macrophages, promote mammary tumor progression and metastasis; however, less
Anderson, Bissell, Blair, Colombatti, Colombo, Condeelis, Coussens, De Palma, Earp, Ghosh, Green, Gunaratne, Hermoso, Hylton, Jensen, Jirstrom, Lewis, Lidereau, Luo, Lydon, Maatta, Machado, Mantovani, Naber, Naldini, Ochiai, Ochoa, Piemonti, Pollard, Pollard, Pollard, Pollard, Pollard, Porse, Rosen, Rosen, Rosen, Sarukhan, Schwertfeger, Schwertfeger, Shen, Strassmann, Suthipintawong, Ullrich, Van Ginderachter, Van Ginderachter, van Rooijen, Visvader, Wang, West   +49 more
core   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Ductal carcinoma in situ of the breast [PDF]

Oncology Reviews, 2009
Ductal carcinoma in situ (DCIS) of the breast is a noninvasive form of breast cancer that has increased in incidence over the past several decades secondary to screening mammography. DCIS now represents 20–30% of all newly diagnosed cases of breast cancer.
Steven J. Buskirk, Jennifer L. Peterson, Stephanie L. Hines, Laura A. Vallow   +3 more
openaire   +2 more sources

Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial [PDF]

, 2014
© Cuzick et al. Open Access article distributed under the terms of CC BY.http://dx.doi.org/10.1016/S1470-2045(14)71171-
Abdi, E, Anderson, E, Atkinson, C, Baum, M, Beith, J, Bird, A, Birrell, S, Blamey, R, Blum, R, Boyages, J, Buser, K, Campbell, I, Cawthorn, S, Cawthorne, Simon, Chapman, C, Chipman, M, Coates, A, Collins, J P, Craft, P, Cuzick, J, Denton, L, Dewar, J, Dowsett, M, Earl, H, Eccles, D, Edwards, R, Evans, G, Fallowfield, L, Fentiman, I, Forbes, J F, Forbes, John F, Friedlander, M, Garcia, J, Gebski, V, George, W, Gilbert, F J, Godbolt, P, Goldhirsch, A, Hamed, H, Hanby, A, Hart, S, Hearne, J, Henry, A, Hirst, C, Holcombe, C, Holli, Kaija, Howell, A, Kealy, R, Kirk, J, Lansdown, M, Lee, M, Lennard, T, Lindsay, D, MacKay, J, MacMichael, K, MacNeil, F, Maddox, P, Mansel, R, McAleese, P, Melmeth, A, Mitine, C, Newton, A, Normand, C, Odling-Smee, W, Oivanen, T, Pagani, O, Paksec, L, Powles, T, Raytor, Z, Richmond, B, Robertson, J, Sainsbury, R, Sauven, P, Seccombe, M, Sestak, Ivana, Simes, R J, Stewart, R, Stotter, A, Thompson, A, Thornto, R, Toy, J, Twentyman, P, Underhill, C, Vergine, Beata, Ward, R, White, S, Wilkinson, A, Wilkinson, S, Williamson, J, Wynne, C   +89 more
core   +2 more sources

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Epidemiology of Ductal Carcinoma In Situ [PDF]

JNCI Monographs, 2010
Ductal carcinoma in situ (DCIS) is a relatively common diagnosis among women undergoing screening mammography. The greatest increases in DCIS incidence have been in non-comedo subtypes of DCIS that are not associated with subsequent invasive cancer. After a 500% increase in DCIS from 1983 to 2003, the incidence of DCIS declined in women aged 50 years ...
openaire   +3 more sources

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source