Results 221 to 230 of about 103,945 (310)

Progress in RNA‐Targeted Therapeutics for Human Diseases

open access: yesMedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang   +10 more
wiley   +1 more source

Integrating Multiple Methods to Validate Key Genes Driving the Progression of Breast Ductal Carcinoma In Situ. [PDF]

open access: yesCurr Issues Mol Biol
Zhong M   +8 more
europepmc   +1 more source

Relationship of the Breast Ductal Carcinoma In Situ Immune Microenvironment with Clinicopathological and Genetic Features

open access: yesClinical Cancer Research, 2017
S. Hendry   +16 more
semanticscholar   +1 more source

Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of Helicobacter pylori‐induced gastritis‐to‐cancer transformation

open access: yesVIEW, Volume 7, Issue 1, February 2026.
H. pylori infection is a major cause of stomach cancer, but its effect on immune cells in tumors is unclear. Using single‐cell sequencing, we mapped the stomach tumor environment and discovered a specific exhausted T‐cell subtype, marked by the FYB1 gene, that is abundant in H. pylori‐positive tumors and linked to patient prognosis. Our findings reveal
Yanhui Yang   +22 more
wiley   +1 more source

Mitigating overtreatment of ductal carcinoma in situ. [PDF]

open access: yesRadiol Adv
Chung HL   +3 more
europepmc   +1 more source

Genome evolution in ductal carcinoma in situ: invasion of the clones

open access: yesJournal of Pathology, 2017
Anna K. Casasent, M. Edgerton, N. Navin
semanticscholar   +1 more source

Contesting the C Word: The Diagnosis of DCIS and Women's Resistance Against Overtreatment

open access: yesSociology of Health &Illness, Volume 48, Issue 2, February 2026.
ABSTRACT DCIS, or ductal carcinoma in situ—also known as Stage 0 breast cancer—accounts for approximately 20 per cent of new breast cancer cases. Although it is noninvasive, treatment typically mirrors that of invasive cancer. Whether DCIS is overtreated remains controversial, even among medical professionals.
Chien‐Juh Gu
wiley   +1 more source

Spatial Location of SPP1+TAMs and Mutually Exclusive Subsets Based on Single‐Cell and Transcriptome Data

open access: yesCancer Science, Volume 117, Issue 2, Page 548-565, February 2026.
This study indicates that SPP1, as an important regulator of tumor progression, is upregulated in various tumors and has been associated with a poor prognosis. SPP1+M2 has a unique spatial location at the forefront of tumor invasion and metastasis, thereby promoting tumor progression. MARCO+M2, which forms a mutually exclusive relationship with SPP1+M2,
Xuan Luo   +15 more
wiley   +1 more source

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