Development of Deferoxamine‐Functionalized Cyclodextrin Polymer for Targeted Iron Chelation
The cyclodextrin polymer is conjugated with 35 deferoxamine units and can form iron(III) complexes. The polymer exhibits significantly lower antiproliferative activity than free deferoxamine. The cyclodextrin polymer with multiple deferoxamine units may present a promising strategy for improving the efficacy of iron chelation therapies.
Roberta Panebianco+2 more
wiley +1 more source
Transpapillary biliary drainage using a forward-viewing endoscope for patients with distal malignant biliary obstruction and type I duodenal stenosis. [PDF]
Hirata Y+16 more
europepmc +1 more source
Abstract Background Oxaliplatin‐induced peripheral neuropathy (OIPN) is a major clinical challenge because it leads to discontinuation of chemotherapy. Omeprazole, a proton pump inhibitor (PPI), has been shown to prevent OIPN in a rat model. Therefore, we aimed to test whether the concomitant use of a PPI reduces oxaliplatin discontinuation due to OIPN.
Keisuke Mine+14 more
wiley +1 more source
Distribution of gut microbiota across intestinal segments and their impact on human physiological and pathological processes. [PDF]
Yang K+9 more
europepmc +1 more source
This review highlights the use of 68Ga‐PSMA PET in prostate cancer (PC) for tumor volume quantification, crucial for staging, treatment planning, and prognosis. Traditional manual segmentation methods are time‐consuming and variable, while AI‐based segmentation techniques, particularly deep learning models like convolutional neural networks, offer ...
Sharjeel Usmani+6 more
wiley +1 more source
Duodenal fluid analysis is an excellent differential diagnosis method of diseases with enterohepatic circulation disturbance. [PDF]
Dong C+5 more
europepmc +1 more source
Erythematous Papules and Plaques in an Infant Receiving Glucagon Therapy
JEADV Clinical Practice, EarlyView.
Sara Al Janahi+4 more
wiley +1 more source
Malignancies and immunoglobulin G4‐related disease
Immunoglobulin G4‐related disease (IgG4‐RD) is associated with increased cancer risk. Malignancies affect both IgG4‐RD involved organs, such as the lung, pancreas, bile duct, and prostate, and noninvolved organs, such as the gastrointestinal duct. B‐cell neoplasms constitute a proportion of the malignancies linked to this disease.
Jingna Li, Wen Zhang
wiley +1 more source
Comparison of the bacterial flora of the duodenum in healthy cats and cats with signs of gastrointestinal tract disease [PDF]
Karen L. Johnston+6 more
openalex +1 more source