Results 41 to 50 of about 61,215 (262)

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

A Retrospective Study on the Clinical Characteristics and Computed Tomography, Biochemical, and Blood Parameters of Duodenal Papillary Diseases

Cancer Control
Objective This study was conducted to investigate the imaging information, laboratory data, and clinical characteristics of duodenal papillary malignancies, aiming to contribute to the early diagnosis of these diseases.
Ning Wang MD, Wenyan Wei MD, Xianguo Qu MD, Jinyan Fang MD, Weixing Mo MD, Qinghai Li MD   +5 more
doaj   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, EarlyView.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source

Efficacy of gel immersion endoscopic ultrasonography for delineating the duodenal papilla and pancreatobiliary ducts: A retrospective study with video

DEN Open, 2023
Objectives Endoscopic ultrasonography is an important examination for periampullary diseases. The duodenum is filled with water to ensure a clear image and distend the duodenal wall without burying the papilla within duodenal folds; however, peristalsis ...
Haruka Toyonaga, Toshifumi Kin, Kosuke Iwano, Risa Nakamura, Takao Shimizu, Koki Chikugo, Tatsuya Ishii, Hiroshi Nasuno, Tsuyoshi Hayashi, Kuniyuki Takahashi, Hajime Yamazaki, Akio Katanuma   +11 more
doaj   +1 more source

Pylorus‐Preserving Gastrectomy for Gastric Cancer: Current Evidence and Future Directions

Annals of Gastroenterological Surgery, EarlyView.
This review aims to outline the current evidence and future directions of PPG, focusing on the feasibility of extending its application beyond its traditional indications. ABSTRACT Pylorus‐preserving gastrectomy (PPG) is a function‐preserving surgery for clinically T1N0M0 (cT1N0M0) early gastric cancer (EGC) located in the middle third of the stomach ...
Sa‐Hong Kim, Hyuk‐Joon Lee
wiley   +1 more source

Surgical outcomes after endoscopic retrograde cholangiopancreatography and sphincterotomy associated duodenal perforations: Experience from a tertiary care centre in India

Current Medicine Research and Practice, 2022
Background: The advent and progress of endoscopic retrograde cholangiopancreatography (ERCP) for hepato-pancreaticobiliary diseases have introduced a paradigm shift in their treatment but have also been associated with complications that have been ...
Srinivas Bojanapu, Uma Vajpeyajula, Aurobindo Prasad Das, Naimish Mehta, Samiran Nundy   +4 more
doaj   +1 more source

Juxtapapillary Duodenal Diverticula and Pancreatobiliary Disease [PDF]

Digestive Surgery, 2010
Juxtapapillary duodenal diverticula (JPD) are observed in around 10–20% of patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). They are acquired extraluminal outpouchings of the duodenal wall through ‘locus minoris resistance’ and their incidence increases with age.
Naoto, Egawa, Hajime, Anjiki, Kensuke, Takuma, Terumi, Kamisawa   +3 more
openaire   +2 more sources

Single‐Incision Laparoscopy‐First Strategy in Crohn's Disease: Risk Factors for Conversion and Surgical Outcomes

Annals of Gastroenterological Surgery, EarlyView.
In this retrospective study of 289 patients with Crohn's disease undergoing a single‐incision laparoscopy‐first (SILS‐first) strategy, conversion to open surgery was required in only 11.8% of cases. Fistula formation, colon resection, and smoking history were identified as independent risk factors for conversion, while postoperative complications and ...
Yuki Horio, Motoi Uchino, Yusuke Tomoo, Kentaro Nagano, Kurando Kusunoki, Ryuichi Kuwahara, Kei Kimura, Kozo Kataoka, Masataka Ikeda, Hiroki Ikeuchi   +9 more
wiley   +1 more source

Prognostic Impact of Metastasis Timing in Metastatic Gastrointestinal Stromal Tumors: A Multicenter Retrospective Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Gastrointestinal stromal tumors (GISTs) commonly metastasize to the liver and peritoneum. Metastases may be detected synchronously at the time of initial diagnosis or develop metachronously after curative‐intent resection. Nonetheless, the prognostic significance of metastasis timing in advanced GIST remains unclear.
Kunihiko Kawai, Tsuyoshi Takahashi, Ryugo Teranishi, Shinsuke Sato, Yukinori Kurokawa, Toshirou Nishida, Seiichi Hirota, Jyunya Fujita, Yuichiro Doki, Toshimasa Tsujinaka   +9 more
wiley   +1 more source