Results 81 to 90 of about 100,338 (295)

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Оцінка лікування виразки дванадцятипалої кишки у дітей з точки зору відновлення репаративної функції = The estimation of treatment in children with duodenal ulcer from the perspective of reparative function recovery

Journal of Education, Health and Sport, 2016
Dudnyk V. M., Buglova N. O. Оцінка лікування виразки дванадцятипалої кишки у дітей з точки зору відновлення репаративної функції = The estimation of treatment in children with duodenal ulcer from the perspective of reparative function recovery.
V. M. Dudnyk, N. O. Buglova
doaj   +3 more sources

Interobserver variation in the endoscopic diagnosis of gastroduodenal ulcer scars: implications for clinical management of NSAIDs users

BMC Research Notes, 2011
Background A clinical history of peptic ulcer has been reported to be associated with a high rate of ulcer recurrence in nonsteroidal anti-inflammatory drug (NSAID) users.
Ishimura Norihisa, Fukuba Nobuhiko, Tada Yasumasa, Okada Mayumi, Yuki Takafumi, Uno Goichi, Amano Yuji, Ishihara Shunji, Kinoshita Yoshikazu   +8 more
doaj   +1 more source

Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes [PDF]

, 2015
The bacterial pathogen Helicobacter pylori commonly colonizes the human gastric mucosa during early childhood and persists throughout life. The organism has evolved multiple mechanisms for evading clearance by the immune system and, despite inducing ...
Robinson, K, White, JR, Winter, JA
core   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

World's longest surviving liver-pancreas recipient [PDF]

, 2007
In July 1988, the liver and pancreas of a cadaveric donor were transplanted separately into a man with type 1 diabetes with end-stage chronic hepatitis B virus.
Alessiani, Calne, Cecka, Farrell, Groth, Lillehei, Petruzzo, Philosophe, Pirenne, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Stratta, Sutherland, Thai, Young   +20 more
core   +1 more source

Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol‐Induced Intestinal Injury via Microbiota‐Dependent and ‐Independent AHR Activation

Advanced Science, EarlyView.
Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui, Beibei Zhang, Jiaxi Tang, Jing Hou, Yueqin Qiu, Kaiguo Gao, Li Wang, Zongyong Jiang, Xuefen Yang   +8 more
wiley   +1 more source

Programmable Semi‐Interpenetrating Living Materials With Robust Stability for Versatile Bioremediation and Biotherapeutics

Advanced Science, EarlyView.
A semi‐interpenetrating engineered living material (sIHSELM), fabricated via thermosensitive hydroxybutyl chitosan and covalent protein self‐assembly, demonstrates exceptional mechanical properties and environmental stability. Shielding bacteria from harsh conditions, sIHSELM exhibits remarkable efficacy in ulcerative colitis treatment and pollutants ...
Zixian Bao, Shengfeng Yang, Dandan Hu, Jiezheng Liu, Bo Jiang, Xinyue Sui, Qingsheng Qi, Lai Li, Guang Zhao   +8 more
wiley   +1 more source

\u3cem\u3eHelicobacter pylori\u3c/em\u3e infection in Havana, Cuba. Prevalence and \u3cem\u3ecagA\u3c/em\u3e status of the strains [PDF]

, 2005
There is a great paucity of information about Helicobacter pylori infection in the countries of the Caribbean basin. Almost no studies have been performed to determine the prevalence, antibiotic resistance or virulence factors of the bacterium.
Camou-Juncas, Christine, del Pilar Escobar, María, Díaz-Canel, Osvaldo, González, Nery, Gutiérrez, Beatriz, Leonard, Ibrahim, Martínez, Rolando, Mendz, George L, Mégraud, Françis, Paniagua, Manuel, Santos, Adriana, Valmaña, Carlos Ernesto, Vidal, Teresita   +12 more
core   +1 more source

The fecal microbiome in dogs with acute diarrhea and idiopathic inflammatory bowel disease. [PDF]

, 2012
Recent molecular studies have revealed a highly complex bacterial assembly in the canine intestinal tract. There is mounting evidence that microbes play an important role in the pathogenesis of acute and chronic enteropathies of dogs, including ...
Cook, Audrey K., Dillman, Enricka M., Dowd, Scot E., García Mazcorro, José Francisco, Heilmann, Romy M., Heimesaat, Markus M., Ivanov, Ivan, Kachroo, Priyanka, Markel, Melissa, Minamoto, Yasushi, Steiner, Jörg M., Suchodolski, Jan S., Toresson, Linda, Unterer, Stefan   +13 more
core   +5 more sources