Results 131 to 140 of about 26,163 (275)

Frailty and Fitness in Older Adults With Acute Myeloid Leukemia: From Chronological Age to Multiparametric Assessment

European Journal of Haematology, EarlyView.
ABSTRACT Acute Myeloid Leukemia predominantly affects older adults, who often present with comorbidities, functional impairment, and frailty, limiting eligibility for intensive chemotherapy or allogeneic transplantation. Historically, treatment options were restricted to hypomethylating agents, low‐dose cytarabine, hydroxyurea, or supportive care, with
Antonella Bruzzese, Enrica Antonia Martino, Santino Caserta, Maria Eugenia Alvaro, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Ernesto Vigna, Massimo Gentile   +11 more
wiley   +1 more source

Variant on Manifestation of Duodenal Metastasis 26 Years after Initial Diagnosis of Primary Cutaneous Melanoma

, 2010
Malignant duodenal neoplasms are relatively rare, and the diagnosis is often delayed because of their vague and nonspecific symptoms. We report the case of a 79-year-old female who had a medical history of malignant melanoma of the cheek that had ...
Jean-Christophe Vaillant, Jean-Michel Siksik, Laurent Hannoun, Kumiko Kitajima, Géraldine Rousseau, Armelle Bardier-Dupas, Sylvie Breton   +6 more
core   +1 more source

Five Advances in Benign Pancreatic Surgery in the Last 50 Years

World Journal of Surgery, EarlyView.
Stephan B. Dreyer, Rowan W. Parks
wiley   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Five Advances for Benign Foregut Surgery in the Last 50 Years

World Journal of Surgery, EarlyView.
David I. Watson, Sarah K. Thompson, John G. Hunter, B. Mark Smithers   +3 more
wiley   +1 more source

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

The FEBS Journal, EarlyView.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger, Alice Wiedmann, Rayan Hassan M. Elshikhidriss, Thomas Brunner   +3 more
wiley   +1 more source

The mask of duodenal tumor in the course of colon cancer

, 2004
Rak dwunastnicy należy do najrzadszych nowotworów przewodu pokarmowego. W każdym przypadku podejrzenia pierwotnego nowotworu dwunastnicy należy rozważyć możliwość, czy jest to nowotwór wychodzący z innego narządu, z wtórnym zajęciem dwunastnicy.
Biniszkiewicz, Tomasz, Sieroń, Aleksander; Katedra i Klinika Chorób Wewnętrznych, Angiologii i Medycyny Fizykalnej Śląskiej Akademii Medycznej, Szpital Specjalistyczny nr 2, Bytom, Arendt, Jerzy, Piecuch, Jerzy, Bilska, Aleksandra, Kubacka, Magdalena   +5 more
core  

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, EarlyView.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source

Efficacy of lymph node dissection for duodenal cancer according to the lymph node station

Annals of Gastroenterological Surgery
Background Lymph node metastasis (LNM) is associated with poor prognosis in patients with duodenal cancer (DC). However, the efficacy and optimal extent of lymph node (LN) dissection have not been thoroughly discussed.
Yuya Miura, Katsuhisa Ohgi, Ryo Ashida, Mihoko Yamada, Shimpei Otsuka, Keiko Sasaki, Katsuhiko Uesaka, Teiichi Sugiura   +7 more
doaj   +1 more source