Results 261 to 270 of about 467,632 (357)

Predisposing conditions in patients with small intestinal adenocarcinomas in the Netherlands: A 20‐year nationwide cohort study

International Journal of Cancer, Volume 157, Issue 2, Page 218-231, 15 July 2025.
What's new? Although small intestinal adenocarcinoma (SIA) shares certain similarities with colorectal cancer, its etiology and predisposing conditions presumably are distinct. Due to the rarity of SIA, however, detailed information on predisposing factors is lacking.
Jasmijn D. G. Linssen, Pascale J. M. Schafrat, Tim R. de Back, Felice N. van Erning, Monique E. van Leerdam, Evelien Dekker, Louis Vermeulen, Ignace H. J. T. de Hingh, Dirkje W. Sommeijer   +8 more
wiley   +1 more source

Antitumor efficacy of intermittent low‐dose erlotinib plus sulindac via MHC upregulation and remodeling of the immune cell niche

International Journal of Cancer, Volume 157, Issue 2, Page 355-370, 15 July 2025.
What's new? Novel immunomodulatory insights derived from experimental models and clinical samples reveal the cancer‐preventive potential of intermittent low‐dose erlotinib plus sulindac (ERL + SUL). This study shows that ERL + SUL treatment upregulates MHC class I and II expression and remodels the immune cell niche, with significant tumor suppression ...
Chakrapani Tripathi, Jorge E. Tovar Perez, Sabeeta Kapoor, Ahmed Muhsin, Wan Mohaiza Dashwood, Yunus Demirhan, Melek Demirhan, Alessandro Shapiro, Altaf Mohammed, Shizuko Sei, Jacklyn Thompson, Mahira Zaheer, Krishna M. Sinha, Powel H. Brown, Michelle I. Savage, Eduardo Vilar, Praveen Rajendran, Roderick H. Dashwood   +17 more
wiley   +1 more source

Unraveling the site-specific features in small intestinal stromal tumors: a retrospective study. [PDF]

BMC Gastroenterol
Wang Q, Li M, Bai X, Zhang R, Ruan S, Ou C, Li J, Li J.   +7 more
europepmc   +1 more source

Gastric adenocarcinoma of fundic gland mucosa arising in heterotopic gastric mucosa of the duodenum: A case report. [PDF]

World J Gastrointest Surg
Yang QY, Xu J, Hu JW, Huang XD.
europepmc   +1 more source

Functional Characterization of a Genetic Variant in the 5′ UTR of APC 1B Promoter in a Familial Adenomatous Polyposis Family

American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
ABSTRACT Pathogenic germline variants in the APC gene result in familial adenomatous polyposis (FAP) which can escalate into colon cancer. Standard clinical testing failed to identify pathogenic variants in a 4‐generation FAP family. We identified and assessed co‐segregation of a 5′ untranslated region (UTR) variant, NM_001127511.3 (APC) c.‐40G>A ...
Brendon Young, Deborah W. Neklason, Kathleen Clark, Bing‐Jian Feng, Megan B. Keener, Thérèse M. Tuohy, Austin Wood, Wendy C. McKinnon, Marc S. Greenblatt, Sean V. Tavtigian   +9 more
wiley   +1 more source

Validation of the ABC Method for Gastric Cancer Risk Stratification Across Helicobacter pylori Infections With Diverse CagA Status and Subtypes in Brazil

Cancer Medicine, Volume 14, Issue 13, July 2025.
This prospective study in Brazil demonstrates the clinical relevance of CagA‐diverse Helicobacter pylori infections for gastric cancer risk assessment. The ABC method reliably identified low‐risk individuals (Group A) and may help reduce unnecessary endoscopies in screening programs, regardless of CagA status and subtypes.
Luis Masuo Maruta, Asuka Furukawa, Heinrich Bender Kohnert Seidler, Aloisio Felipe‐Silva, Keisuke Uchida, Daisuke Kobayashi, Kurara Yamamoto, Junko Minami, Masaki Sekine, Minako Takagi, Renato Takayuki Hassegawa, Eduardo Koji Marchi Ogawa, Rodrigo Barbosa Villaça, Tecio de Araujo Couto, Jorge Alberto Capra Biasuz, Edmar Tafner, Ana Luiza Werneck‐Silva, Simone Perez Pilli, José Guilherme Nogueira da Silva, Leonard Medeiros da Silva, Ricardo Ambrosio Fock, Chinatsu Ogura, Yumi Mizuguchi, Keiko Miura, Kouhei Yamamoto, Yoshinobu Eishi, Kenichi Ohashi   +26 more
wiley   +1 more source

The Role of Iron Chelation Therapy in Colorectal Cancer: A Systematic Review on Its Mechanisms and Therapeutic Potential

Cancer Medicine, Volume 14, Issue 13, July 2025.
Iron chelation is a promising yet underexplored strategy for colorectal cancer (CRC) treatment. Iron chelators have a dual role in inhibiting and potentially promoting cancer progression. Iron chelation affects key CRC pathways, including histone methylation, NDRG1 upregulation, Wnt/β‐catenin, and p53 modulation.
Gihani Vidanapathirana, Md Sajedul Islam, Sujani Gamage, Alfred K. Lam, Vinod Gopalan   +4 more
wiley   +1 more source

Correlation of Gastroduodenoscopic Findings With Histopathological Diagnosis of Gastroduodenal Biopsy. [PDF]

Cureus
Choudhary M, Yadav S, Kumar R, Yadav K, Sengar M, Chaudhary R.   +5 more
europepmc   +1 more source

Rare Metastatic Pathways of Renal Cell Carcinoma: Duodenal Involvement and Therapeutic Challenges

Clinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT Duodenal metastasis from renal cell carcinoma (RCC), though rare, warrants consideration in patients with unexplained gastrointestinal (GI) symptoms. Endoscopic evaluation and immunohistochemistry (IHC) are essential for accurate diagnosis, while molecular profiling helps identify mutations influencing disease behavior and treatment response ...
Supriya Peshin, Faizan Bashir, Nagaishwarya Moka   +2 more
wiley   +1 more source

Clinical insights into Wilkie's syndrome: A case report and review of relevant literature. [PDF]

Radiol Case Rep
Ledezma Flores E, Calderón Fernández A, Urias Pompa A, Pompa González LM.   +3 more
europepmc   +1 more source