Results 181 to 190 of about 39,068 (254)

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan   +3 more
wiley   +1 more source

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

open access: yesHistopathology, Volume 89, Issue 3, Page 442-455, September 2026.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello   +20 more
wiley   +1 more source

Imaging Characteristics of Pylorogastric, Duodenogastric, and True‐Gastrogastric Intussusception in 25 Dogs and One Cat

open access: yesVeterinary Radiology &Ultrasound, Volume 67, Issue 5, September 2026.
ABSTRACT Gastric intussusception in dogs and cats is uncommon, and there are multiple variations described in the literature. The aim of this study was to describe the imaging characteristics of pylorogastric (PG), duodenogastric (DG), and true‐gastrogastric (true‐GG) intussusceptions.
Dylan Burton   +9 more
wiley   +1 more source

Assessment of dose distribution in pancreatic SABR in the presence of a metallic biliary stent using Monte Carlo modeling

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract Background Stereotactic ablative radiotherapy (SABR) with dose escalation is increasingly used for pancreatic cancer; however, the dosimetric impact of metallic biliary stents remains poorly characterized. Self‐expanding metal stents (SEMS), commonly placed for obstructive jaundice, contain high‐density nitinol that produces computed ...
Ahmad Abbas   +2 more
wiley   +1 more source

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

open access: yesAnimal Research and One Health, Volume 4, Issue 3, Page 261-277, August 2026.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao   +6 more
wiley   +1 more source

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