Monoclonal antibodies in type 2 asthma : a systematic review and network meta-analysis [PDF]
, 2019 Since novel treatments to target eosinophilic inflammation in Type 2 asthma are emerging, we aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate.
De Feyter, Silke +4 more
core +1 more source
BMC Pulmonary Medicine, 2023 Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis characterized by eosinophil-rich granulomatous inflammation and small-to-medium vessel vasculitis associated ...
Isao Suzaki +6 more
doaj +1 more source
Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. [PDF]
, 2019 Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the ...
Barton, Gregory M +11 more
core +1 more source
Shrinkage estimation for dose-response modeling in phase II trials with multiple schedules
, 2020 Recently, phase II trials with multiple schedules (frequency of administrations) have become more popular, for instance in the development of treatments for atopic dermatitis.
Friede, Tim +2 more
core +1 more source
Diagnosis and management of eosinophilic asthma: a US perspective. [PDF]
, 2014 Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and ...
Doherty, Taylor A, Walford, Hannah H
core +1 more source
Dupilumab: A new paradigm for the treatment of allergic diseases [PDF]
, 2018 Moderate and severe forms of allergic diseases such as atopic dermatitis and asthma are a challenge for clinicians. In these conditions, which severely affect the quality of life of the patient and frequently have associated allergic comorbidities, the ...
Dávila, Ignacio, Sastre, Joaquín
core +2 more sources
How Can Dupilumab Cause Eosinophilic Pneumonia?
Biomolecules, 2022 Reports of eosinophilic pneumonia (EP) as a side effect of dupilumab administration are limited in previous studies. Herein, we report two cases in which EP developed subsequent to the administration of dupilumab for eosinophilic chronic rhinosinusitis ...
Momoko Kurihara +14 more
doaj +1 more source
Feasibility Analysis of Interleukin-13 as a Target for a Therapeutic Vaccine [PDF]
, 2019 Background: The development of therapeutic vaccines requires thorough knowledge of potential hazards associated with long-term inactivation of self-proteins.
Foerster, John, Molęda, Aleksandra
core +2 more sources
Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. [PDF]
, 2018 Inflammatory cytokines are commonly elevated in acute depression and are associated with resistance to monoaminergic treatment. To examine the potential role of cytokines in the pathogenesis and treatment of depression, we carried out a systematic review
A Hinz +76 more
core +5 more sources
Cicatricial ectropion in a patient treated with dupilumab
American Journal of Ophthalmology Case Reports, 2017 Purpose: To describe a case of bilateral conjunctivitis and cicatricial ectropion associated with dupilumab therapy for atopic dermatitis. Observations: Severe hyperemia of the conjunctiva and eyelid margins, as well as cicatricial ectropion, began two ...
Alexander C. Barnes +2 more
doaj +1 more source