Results 11 to 20 of about 409 (95)
Highly efficient transgene-free ErCas12a RNP-protoplast genome editing and single-cell regeneration in Nicotiana benthamiana for glyco-engineering. [PDF]
Plant Biotechnol JSummary Nicotiana benthamiana serves as a unique platform for biopharmaceutical production, offering advantages such as efficient and scalable protein synthesis. In addition, custom N‐glycans can be engineered on biopharmaceutical glycoproteins. Yet, plant‐native glycosyltransferases and glycoside hydrolases need to be removed to prevent undesired ...
Blumberg LC +8 more
europepmc +2 more sources
Prediction of outcome after ligation or thin film banding of extrahepatic shunts, based on plasma albumin concentration and hematologic expression of 8 target genes in 85 dogs. [PDF]
J Vet Intern Med, 2023 Abstract Background In dogs with a congenital extrahepatic portosystemic shunt (EHPSS), outcome after surgical attenuation is difficult to predict. Objectives Develop a minimally invasive test to predict outcome after surgical EHPSS attenuation and establish risk factors for postattenuation seizures (PAS). Animals Eighty‐five client‐owned dogs referred
van Blokland-Post K +5 more
europepmc +2 more sources
Developmental Science, Volume 26, Issue 6, November 2023., 2023 Abstract Across the early childhood period of development, young children exhibit considerable growth in their executive functioning (EF) and vocabulary abilities. Understanding the developmental trajectory of these seemingly interrelated processes is important as both early vocabulary and EF have been shown to predict critical academic and socio ...
Madeleine Bruce +2 more
wiley +1 more source
Middle childhood attachment‐based family therapy: Theory and model description
Family Process, Volume 62, Issue 3, Page 1040-1054, September 2023., 2023 Abstract In middle childhood, the first manifestations of mental health problems can emerge and become a precursor of mental health issues in adolescence. Given that weak parent–child attachment can contribute to this distress, it is possible that strengthening the attachment bond could reduce risk trajectory.
Leen Van Vlierberghe +2 more
wiley +1 more source
Review of Education, Volume 11, Issue 2, August 2023., 2023 Abstract Physical manipulatives (PMs) are concrete objects used during hands‐on learning activities (e.g., building blocks, fraction tiles, counters), and are widely used in primary‐school teaching, especially during maths instruction. This scoping review collated studies that have examined the effectiveness of educational PM interventions with pre ...
Elizabeth M. Byrne +3 more
wiley +1 more source
Early childhood stress responses to psychosocial stressors: The state of the science
Developmental Psychobiology, Volume 64, Issue 7, November 2022., 2022 Abstract The aim of this systematic review was to better understand whether and to what extent psychosocial stressors are associated with hypothalamic–pituitary–adrenal axis or autonomic nervous system stress responses in young children (1–6 years of age).
Randi A. Bates +4 more
wiley +1 more source
Child Development, Volume 93, Issue 6, Page e656-e671, November/December 2022., 2022 Abstract Several studies have previously investigated the effects of sticky mittens training on reaching and grasping development. However, recent critique casted doubts on the robustness of the motor effect of this training. The current study presents a pre‐registered report that aimed to generalize these effects to Swedish infants.
Linda van den Berg +5 more
wiley +1 more source
Sex‐dependent influence of postweaning environmental enrichment in Angelman syndrome model mice
Brain and Behavior, Volume 12, Issue 2, February 2022., 2022 Environmental enrichment (EE) is a powerful behavioral manipulation that may provide a route to ameliorating the symptoms of some brain disorders. In this application of EE in mice modeling Angelman syndrome (AS), a rare neurodevelopmental disorder, we found that this intervention can correct a wide range of robust behavioral deficits commonly seen in ...
Jameson A. Cosgrove +3 more
wiley +1 more source
Infant and Child Development, Volume 30, Issue 6, November/December 2021., 2021 Abstract Preterm birth is associated with reduced social attention in infancy. Are these early social attention differences linked to later interactive ability? This study draws on a well‐characterized preterm cohort in whom we have previously demonstrated a reduced attentional preference for social information in infancy, using eye‐tracking. States of
Bethan Dean +7 more
wiley +1 more source
Aging Cell, Volume 20, Issue 9, September 2021., 2021 Neuroregeneration after stab‐wound injury is incomplete in aged killifish, caused by reduced proliferation of specialized non‐glial progenitors (NGPs) and mammalian‐like glial scarring. It seems that aged killifish deploy the restricted regenerative program, typically associated with mammals, instead of successful neurorepair as shown here for young ...
Jolien Van houcke +7 more
wiley +1 more source