Results 111 to 120 of about 6,984,569 (278)

A model for accelerating a life cycle of research and development based on example of development of genetic cell re-programming

Ekonomika Nauki, 2016
An analysis was conducted of a model for accelerating the life cycle of research and development, as well as temporary parameters for transforming fundamental industrial perspective using an example of reprogramming technologies for obtaining induced ...
L. A. Tsvetkova
doaj  

A 131-year evidence of more extreme and higher total amount of hourly precipitation in Hong Kong

Environmental Research Letters
Based on the observations of hourly precipitation for 131 years from Hong Kong Observatory Headquarters, this study examined the long-term changes in the characteristics of hourly precipitation extremes in terms of intensity, total precipitation amount ...
Yangchen Lai, Jianfeng Li, Tsz-cheung Lee, Wai-Po Tse, Faith Ka Shun Chan, Yongqin David Chen, Xihui Gu   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Effects of biomass smoke on pulmonary functions: a case control study

International Journal of COPD, 2016
Baran Balcan,1 Selcuk Akan,2 Aylin Ozsancak Ugurlu,1 Bahar Ozcelik Handemir,3 Berrin Bagcı Ceyhan,4 Sevket Ozkaya5 1Department of Pulmonary Medicine, Baskent University Faculty of Medicine, Istanbul, 2Department of Internal Medicine, Ankara Education ...
Balcan B, Akan S, Ugurlu AO, Handemir BO, Ceyhan BB, Ozkaya S   +5 more
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Storage of plasma-derived exosomes: evaluation of anticoagulant use and preserving temperatures

Platelets
Exosomes carry large cargo of proteins, lipids, and nucleic acids, serving as versatile biomarkers for disease diagnosis and vehicles for drug delivery.
Caiting Yang, Jie Han, Hai Liu, Yuyu He, Zhenhua Zhang, Xiaochun Liu, Farooq Waqas, Lizhong Zhang, Huiping Duan, Jing He, Li Dong   +10 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

THINKING THROUGH DURATION

Anthropology Today, 2016
This narrative offers an alternative Jewish Israeli ‘duration’ of the abduction described by Dalsheim. It agrees that the weight of past experience shapes both present perception and future imagination, reproducing the sense of ‘intractable’ conflict but argues that subjective and collective experience is mediated by what C. Wright
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source