Results 131 to 140 of about 9,046,003 (326)

Mapping boundaries: Microprosodic and dialectal variability in the perception of Estonian long and overlong quantity

Eesti Rakenduslingvistika Ühingu Aastaraamat
This paper presents the results of a web-based perception experiment that tested the distinction of long (Q2) and overlong (Q3) quantity degrees in Estonian. Firstly, we observe an effect of segmental quality on the perception of quantity.
Pärtel Lippus, Liis Kask, Sofia Lutter, Nele Põldver, Kairi Kreegipuu   +4 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Benefit Duration, Unemployment Duration and Job Match Quality: A Regression-Discontinuity Approach [PDF]

The generosity of the Unemployment Insurance system (UI) plays a central role for the job search behavior of unemployed individuals. Standard search theory predicts that an increase in UI benefit generosity, either in terms of benefit duration or ...
Caliendo, Marco, Tatsiramos, Konstantinos, Uhlendorff, Arne   +2 more
core  

Duration problem: basic concept and some extensions

, 2016
We consider a sequence of independent random variables with the known distribution observed sequentially. The observation $n$ is assumed to be a value of one order statistics such as s:n-th, where 1 is less than s is less than n.
Porosiński, Zdzisław, Skarupski, Marek, Szajowski, Krzysztof   +2 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A model for accelerating a life cycle of research and development based on example of development of genetic cell re-programming

Ekonomika Nauki, 2016
An analysis was conducted of a model for accelerating the life cycle of research and development, as well as temporary parameters for transforming fundamental industrial perspective using an example of reprogramming technologies for obtaining induced ...
L. A. Tsvetkova
doaj  

A 131-year evidence of more extreme and higher total amount of hourly precipitation in Hong Kong

Environmental Research Letters
Based on the observations of hourly precipitation for 131 years from Hong Kong Observatory Headquarters, this study examined the long-term changes in the characteristics of hourly precipitation extremes in terms of intensity, total precipitation amount ...
Yangchen Lai, Jianfeng Li, Tsz-cheung Lee, Wai-Po Tse, Faith Ka Shun Chan, Yongqin David Chen, Xihui Gu   +6 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source