Results 211 to 220 of about 1,947,585 (349)

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Clinical presentation and outcomes of medullary thyroid cancer in two European countries: impact of diagnostic strategies. [PDF]

Eur Thyroid J
Ceruti D, Bonenkamp HJ, Colombo C, Gotthardt M, De Leo S, van Herwaarden AE, Ottevanger PB, Netea-Maier RT, Fugazzola L.   +8 more
europepmc   +1 more source

Prescribing variation across Europe: Insights into prescribing practices and educational needs

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing medication is a complex process, influenced by many factors that can be weighed differently. Four prescriber profiles have been identified: pragmatic‐contextual, guideline‐oriented, experience‐driven and vulnerability‐focused. However, the extent to which European prescribers identify with these profiles and the role of these profiles ...
Mariëlle G. Hartjes, Milan C. Richir, Michiel A. van Agtmael, Jelle Tichelaar   +3 more
wiley   +1 more source

Knowledge networks in the Dutch aviation industry: The proximity paradox

, 2012
Tom Broekel, R. Boschma
semanticscholar   +1 more source

Ethnic variation in thoracic aortic dimensions in the general population: a comparison between Indian and Dutch populations. [PDF]

Open Heart
Bacour N, Idhrees M, Samraj J, Grewal S, Velayudhan B, Busra Celik N, Zafar M, Elefteriades JA, Grewal N.   +8 more
europepmc   +1 more source

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source

Patients with tumor deposits benefit equally from adjuvant therapy compared to other stage III colon cancer groups: two retrospective population-based studies. [PDF]

BMC Cancer
Erdogan ASO, Shu Y, Gootjes E, Simmer F, Nagtegaal ID.   +4 more
europepmc   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Association of benzodiazepine and opioid use with hip fracture treated with arthroplasty: a nationwide case-control study. [PDF]

BMC Geriatr
Yepes-Calderón M, Nelissen RGHH, Bouvy ML, van Steenbergen LN, Dahan A, Rosendaal FR, Gademan MGJ.   +6 more
europepmc   +1 more source

Prevalence and impact of prescribing cascades in community‐dwelling adults: Longitudinal analysis of the Irish longitudinal study on ageing (TILDA)

British Journal of Clinical Pharmacology, EarlyView.
Prescribing cascades occur when medication is prescribed to prevent/treat the adverse effects of another medication and may be intentional/unintentional. This study examines the prevalence of nine prescribing cascades (ThinkCascades) in The Irish Longitudinal StuDy on Ageing (TILDA).
Ann Sinéad Doherty, Rose Anne Kenny, Frank Moriarty, Fiona Boland, Barbara Clyne, Tom Fahey, Denis O' Mahony, Emma Wallace   +7 more
wiley   +1 more source