Results 241 to 250 of about 1,947,585 (349)

Pharmacokinetics and pharmacodynamics of intravenous and oral (S)‐ketamine: Investigating metabolite contribution to subjective effects

British Journal of Clinical Pharmacology, EarlyView.
Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto, Gabriël E. Jacobs, Joost C. van Mechelen, Laura G. J. M. Borghans, Johan G. C. van Hasselt, Linda B. S. Aulin   +5 more
wiley   +1 more source

Direct Prediction of VLCADD Severity Using Newborn Screening Analyte Data. [PDF]

J Inherit Metab Dis
Schwantje M, Maase RE, Dekkers E, Ferdinandusse S, Vaz FM, Hörster F, Mütze U, Grünert SC, Visser G, Velden MGMS, Fuchs SA.   +10 more
europepmc   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis. [PDF]

Dialogues Clin Neurosci
Bai CH, Fan HY, Lin HA, Lin SF.
europepmc   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, EarlyView.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

Implementation and product- and process evaluation of a co-created gender-informed and culturally-sensitive toolkit to improve symptom recognition and care seeking for ischemic heart disease: RE-AIM framework. [PDF]

PLoS One
Hummel B, van Schalkwijk DL, Zipfel N, Tuithof PTC, Mommersteeg PMC, Harskamp RE, van Valkengoed IGM.   +6 more
europepmc   +1 more source

Why do people choose to enter and exit the teaching profession? An interdisciplinary quantitative synthesis

British Educational Research Journal, EarlyView.
Abstract Many nations experience recurring shortages of teachers in particular subjects, prompting concerns that pupils' education is suffering as a result. Researchers have responded by generating a sizable literature on the reasons for which people enter and exit the teaching profession.
Sam Sims, Harriet Lowes‐Belk, Clare Routledge   +2 more
wiley   +1 more source

Teacher‐makers and teacher‐breakers: (Re)defining how status and safety influence trajectories into and away from teaching

British Educational Research Journal, EarlyView.
Abstract This paper uses empirical data from a longitudinal qualitative study conducted with aspirant teachers in England to propose (re)definitions of the concepts of ‘status’ and ‘safety’ as a framework with which to understand and improve teacher recruitment.
Emily MacLeod
wiley   +1 more source

Beyond Intention: An Exploration on How Precision Fermentation Technology for Animal-Free Cheese may Affect the Meaning of Cheese. [PDF]

Food Ethics
Bouma R, Hettinga K, Hase Ueta M, Robaey Z.   +3 more
europepmc   +1 more source

System failure? Exploring the interplay of fear of failure, competition, cooperation and sense of belonging in education in England and Flanders

British Educational Research Journal, EarlyView.
Abstract Fear of failure is damaging in a host of ways yet is rife in many schools. Drawing on self‐worth theory, we explore whether fear of academic failure is higher in education systems with features that increase students' experiences of competition. To do this, we compare two very different education systems: England, where, for instance, national
Carolyn Jackson, Mieke Van Houtte
wiley   +1 more source