Results 131 to 140 of about 130,149 (260)

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Repurposing Registries: Completeness of Real‐World Data for Regulatory and HTA Purposes in Three Cancer‐Focused Registries

Clinical Pharmacology &Therapeutics, EarlyView.
Despite developments in supporting the identification and selection of fit‐for‐purpose registries, a translational gap remains between the original purposes of clinically focused registries and their current and future expected use in policymaking. This study aimed to assess the extent to which cancer‐focused registries collect essential data elements ...
Manon C. Wilpshaar, Doranne Hilarius, Luisa Prada, Ansgar Weltermann, Christine Leopold   +4 more
wiley   +1 more source

Psychiatric Morbidity Is Overrepresented in Young Girls at High Risk of Developing Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Psychiatric comorbidity frequently presents in anorexia nervosa (AN). Yet, the premorbid mental health status is relatively unknown. The aim of this study was to map out psychiatric morbidity and psychopathology among girls at familial high risk (FHR) of developing AN, thereby detecting possible underlying vulnerabilities preceding ...
Karin Dahlin, Kajsa Järvholm, Jovanna Dahlgren, Elisabet Wentz   +3 more
wiley   +1 more source

Determinants of the quality of life of patients with NF2-related schwannomatosis and validation of the Dutch NFTI-QOL questionnaire. [PDF]

Fam Cancer
Tops AL, Goemans D, Aten E, Schopman JE, Koot RW, Gelderblom H, Jansen JC, Hensen EF.   +7 more
europepmc   +1 more source

Radical Listening as a Governance Innovation: Integrating Planetary Health and Community‐Led Forest Conservation in Indonesia

Environmental Policy and Governance, EarlyView.
ABSTRACT While REDD+ prioritizes carbon sequestration, its narrow focus often overlooks forest‐health linkages critical to community well‐being. This paper examines the holistic model of Health in Harmony (HIH) and Alam Sehat Lestari (ASRI), which integrates forest conservation with healthcare through radical listening—a decolonial community engagement
Angie Hsu, Nur Febriani, Luce Alvafritz, Firdani Asri   +3 more
wiley   +1 more source

Endogenously generated Dutch-type Aβ non-fibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation. [PDF]

Alzheimers Dement
Castranio EL, Varghese M, Argyrousi EK, Tripathi K, Huang Y, Asada A, Söderberg L, Bresnahan E, Lerner D, Garretti F, Zhang H, van de Loo J, Stimpson CD, Talty R, Glabe C, Levy E, Wang M, Ilkov M, Suzuki T, Ando K, Zhang B, Lannfelt L, Guérin B, Lubell WD, Rahimipour S, Dickstein DL, Gandy S, Arancio O, Ehrlich ME.   +28 more
europepmc   +1 more source

The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 733-760, April 2025.
Abstract Implantable cardioverter defibrillators (ICDs) reliably prevent death due to life‐threatening arrhythmias; this may become less relevant in people with more severe heart failure who are reaching the end of life (EOL). This review aimed to explore the ICD deactivation process and identify ethical issues, especially around the initiation of ...
Siobhan C. Murray, Claire McNamara, Anna V. Chatzi   +2 more
wiley   +1 more source

Impact of COVID-19 pandemic on surgical cancer care disparities according to socioeconomic status. [PDF]

Public Health Pract (Oxf)
van Vuren RMG, van den Hoek R, Kruijff S, Heineman DJ, Kok NFM, Swijnenburg RJ, Visser MR, Gisbertz SS, Hendriks TE, de Vos-Geelen J, van der Plas WY, Wouters MWJM.   +11 more
europepmc   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Scarcity by design: famine, structural violence, and the biosocial inheritance of political deprivation. [PDF]

Front Public Health
Eftekhari A, Aker A, Uppalapati K, Wispelwey B.   +3 more
europepmc   +1 more source