Results 101 to 110 of about 3,842,952 (321)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Asynchronous Low Duty-Cycling for Reduced Event-Reporting Delay in Underwater Acoustic Sensor Networks

IEEE Access
Event-driven Underwater Acoustic Sensor Networks (UASNs) face the critical challenge of minimizing event-reporting delay while maintaining energy efficiency in resource-constrained underwater environments.
Slavica Tomovic, Benjamin Sherlock, Jeffrey Neasham, Igor Radusinovic   +3 more
doaj   +1 more source

Q-Learning Based Fair and Efficient Coexistence of LTE in Unlicensed Band

Sensors, 2019
The increased demand for spectrum resources for multimedia communications and a limited licensed spectrum have led to widespread concern regarding the operation of long term evolution (LTE) in the unlicensed (LTE-U) band for internet of things (IoT ...
Rojeena Bajracharya, Rakesh Shrestha, Sung Won Kim   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Adaptive Duty-Cycling to Enhance Topology Control Schemes in Wireless Sensor Networks

International Journal of Distributed Sensor Networks, 2014
To prolong the network lifetime, various scheduling approaches that schedule wireless devices of nodes to switch between active and sleep states have been studied.
Myungsu Cha, Mihui Kim, Dongsoo S. Kim, Hyunseung Choo   +3 more
doaj   +1 more source

A Tuned-RF Duty-Cycled Wake-Up Receiver with −90 dBm Sensitivity

Sensors, 2017
A novel wake-up receiver for wireless sensor networks is introduced. It operates with a modified medium access protocol (MAC), allowing low-energy consumption and practical latency.
Sadok Bdiri, Faouzi Derbel, Olfa Kanoun
doaj   +1 more source

Resonant Few-Photon Excitation of a Single-Ion Oscillator

, 2012
We study the motion of an undamped single-ion harmonic oscillator, resonantly driven with a pulsed radiation pressure force. We demonstrate that a barium ion, initially cooled to the Doppler limit, quickly phase locks to the drive and builds up coherent ...
Lin, Y. -W., Odom, B. C., Williams, S.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A 75-pJ/bit 435-MHz 16-QAM Modulator With 20-ns Startup Time and Symbol-Level Duty Cycling for Capsule Endoscopy

IEEE Open Journal of the Solid-State Circuits Society
Wireless capsule endoscopy requires simultaneous support of ultralow-power operation and high data rate to enable long diagnostic time and reliable image transmission.
Donghyun Youn, Daehyeon Kwon, Minkyu Je
doaj   +1 more source

Predictive Duty Cycle Adaptation for Wireless Camera Networks [PDF]

, 2011
Wireless sensor networks (WSN) typically employ dynamic duty cycle schemes to efficiently handle different patterns of communication traffic in the network.
Kak, Avinash, Medeiros, Henry, Park, Johnny, Shin, Paul J.   +3 more
core   +1 more source