Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Voltage-to-Duty Ratio Convertor [PDF]
In this paper, we describe an A / D conversion circuit for converting the duty ratio of a voltage from the Op-amp and resistor and capacitor.
25616 +7 more
core +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Investigation of enhancing EDM machining performance of INCONEL alloy using composite electrodes
In this research, an attempt was made to reinforce aluminium with graphite particles and use it as a tool material with the objective of combining the properties of aluminium and graphite.
Shabarinathan KT +3 more
doaj +1 more source
Dynamic Duty-Cycle MAC Protocol for IoT Environments and Wireless Sensor Networks
This paper proposes a new protocol that can be used to reduce transmission delay and energy consumption effectively. This will be done by adjusting the duty-cycle (DC) ratio of the receiver node and the contention window size of the sender node according
Gayoung Kim, Jin-Gu Kang, Minjoong Rim
doaj +1 more source
High Gain Transformer-Less Double-Duty-Triple-Mode DC/DC Converter for DC Microgrid [PDF]
High-gain DC/DC converters with high efficiency are needed in dc microgrid owed to the low voltage of power sources, e.g., photovoltaic-cell and fuel-cell.
Meraj, Mohammad +17 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Modeling the System for Hybrid Renewable Energy Using Highly Efficient Converters and Generator
High-efficient isolated DC/DC converters with a high-efficiency synchronous reluctance generator (SRG) are the ultimate solutions in DC microgrid systems.
Tefera Kitaba
doaj +1 more source
Optimal control of torque ripple for direct torque control system of mine hoist
In view of problem of large torque ripple existed in low speed range of direct torque control system of mine hoist, an optimal control method of torque ripple for mine hoist was proposed.
WANG Zhen, CHEN Zhaolei, CAO Xiaodong
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source

