Results 161 to 170 of about 504,488 (196)

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

Intratumoral bacteria engineered for tumor therapy

Interdisciplinary Medicine, EarlyView.
This article comprehensively reviews engineered intratumoral bacteria used in tumor therapy. The concept development, characteristics, and engineering methods of intratumoral bacteria are summarized. The mechanisms and the translational significance by which engineered intratumoral bacteria interfere with tumor progression are discussed and highlighted.
Huajie Zhang, Zelin Chen, Zeyu Yao, Sishi Luo, Cheng Luo, Rui Yang, Hao Fu, Songyin Huang   +7 more
wiley   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Radiographic changes in the maxillary sinus following closed sinus augmentation

Journal of Periodontology, EarlyView.
Abstract Background The primary objective of this study is to evaluate the accuracy of 3‐dimensional (3D) imaging in detecting radiographic and morphological graft changes compared to traditional 2‐dimensional (2D) imaging. Additionally, the study aims to assess the distribution of graft material and the extent of resorption occurring between baseline ...
Jaret O. Simonsen, Michael P. Mills, Brian L. Mealey, Lea El Hachem, Hassem Geha, Kerri Font, Charles A. Powell   +6 more
wiley   +1 more source

Step‐by‐step insight into gait analysis: A narrative review unlocking knee biomechanics

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Gait analysis offers a powerful tool for clinical and orthopaedic decision‐making. By quantifying spatiotemporal, kinematic and kinetic parameters during walking, it provides a dynamic window into joint function that static imaging cannot capture.
Giovanni Spallone, Letizia Mancini, Arianna Carnevale, Stefano Campi, Alessandro de Sire, Emiliano Schena, Pieter D'Hooghe, Michael T. Hirschmann, Rocco Papalia, Umile Giuseppe Longo   +9 more
wiley   +1 more source

Spatiotemporal dynamics of brain function network during proprioception rehabilitation after anterior cruciate ligament reconstruction: A randomized trial

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
The improvement of proprioceptive function after ACLR is related to the optimization of spatiotemporal dynamics of SM, CC, DM, CB and VI functional networks. Rehabilitation optimization can incorporate visual–cognitive dual‐task exercises. Abstract Purpose In this study, we aimed to examine the dynamic functional network connectivity (dFNC) patterns ...
Xiaoyun Zhuang, Chunmei Sui, Xuesong Han, Xiaoying Liu, Xiaoyang Wang, Xiumei Zhu, Ming Xu, Yin Qin   +7 more
wiley   +1 more source

Artificial intelligence in orthopaedics: Enhanced examinations, ambient intelligence and the future of clinical practice

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Artificial intelligence (AI) continues to rapidly transform the practice of medicine, with clinicians increasingly adopting data‐driven decision‐making aids and diagnostic support tools. Orthopaedic physicians are well poised to harness the capabilities of AI, with an abundance of quantifiable imaging, biomechanical data, and structured ...
Alexander Bouterse, James A. Pruneski, Felix C. Oettl, Balint Zsidai, Thomas Tischer, Umile Giuseppe Longo, Romain Seil, Michael T. Hirschmann, Kristian Samuelsson   +8 more
wiley   +1 more source

Dual 1550‐nm Erbium Glass Fiber and 1927‐nm Thulium Fiber Non‐ablative Fractional Laser System Treatment in Patients With Skin of Color: A Review of Clinical Studies and Unmet Needs

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives To review the efficacy and safety of the dual 1550‐nm erbium glass fiber and 1927‐nm thulium fiber non‐ablative fractional laser system in patients with skin of color (ie, Fitzpatrick skin types [FSTs] III–VI). Materials and Methods Efficacy, safety, and histologic outcomes were reviewed from 15 clinical studies examining the use of
Mitchel P. Goldman, Douglas C. Wu, Shilpi Khetarpal, Abby Jacobson, Jordan V. Wang, Roy G. Geronemus   +5 more
wiley   +1 more source