Results 71 to 80 of about 446,830 (297)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The effect of Na2S2O8 oxidant on improving the efficiency of photo-catalytic process of nano-TiO2 immobilized on concrete in DB71 removal

سلامت و محیط, 2014
Background and Objective: Most of the dyes used in the textile industries can be toxic and carcinogenic. One of the suitable technologies to remove them is advanced oxidation processes.
Masoumeh Panbehkar Bishe, Bita Ayati
doaj  

Optimization of Red 46 Dye Removal Using Magnetic Polymeric Adsorbent Prepared from Polyacrilonitrile Fibers [PDF]

آب و فاضلاب, 2019
Textile industry wastewater in additions toxicity for organisms led to changes as decreased of water transparency and sunlight penetration and increase in chemical oxygen demand.
Kamran Rahimi, Rouhollah Mirzaei, Ahmad Akbari, Nourollah Mirghaffari, Arash Yoonesnia   +4 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Using Eggshell in Acid Orange 2 Dye Removal from Aqueous Solution

علوم بهداشتی ایران, 2015
Background and purpose: Generated dye wastewater by the textile industry is usually toxic, non-biodegradable and resistant in the environment. Eggshell is one of the inexpensive material and for the reason the vesicular structures can be used as a proper
Ahmad Reza Yari, Gharib Majidi, Mehdi Tanhaye Reshvanloo, Mohsen ansari, Shahram Nazari, Meysam Emami Kale Sar, Mohammad Khazaei, Maryam Sadat Tabatabai-Majd   +7 more
doaj  

Adsorption efficiency of carbon prepared from agricultural waste materials in removing basic dye from aqueous solution [PDF]

, 2011
Management of solid waste is the burgeoning issue of the current times. Agriculture waste is rich in org. material like cellulose, lignin etc. and can be of great use if utilized as right resource at right time and right place.
Nandini, N., Sucharita Tandon, .
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Assessing the efficiency of Fe:TiO2 nanoparticles in removal of Cat Blue 41 using sunlight irradiation in aqueous media using Response surface method (RSM) [PDF]

محیط زیست و مهندسی آب, 2016
Nowadays, protecting environment, especially aqueous medium is a crucial task in modern world. Because of their nature, dyes have not only negative impacts on the aesthetic aspects of the environment, but also result in serious biological and chemical ...
Yahya Zandsalimi, Behzad Shahmoradi, Afshin Maleki, K. Byrappa   +3 more
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source