Results 121 to 130 of about 8,896,910 (302)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Dynamic Time Warping (DTW) distance is a popular similarity measure for polygonal curves (i.e., sequences of points). It finds many theoretical and practical applications, especially for temporal data, and is known to be a robust, outlier-insensitive alternative to the \frechet distance. For static curves of at most $n$ points, the DTW distance can
Bringmann, Karl +5 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Portable dynamic fundus instrument [PDF]
, 1992 A portable diagnostic image analysis instrument is disclosed for retinal funduscopy in which an eye fundus image is optically processed by a lens system to a charge coupled device (CCD) which produces recordable and viewable output data and is ...
Caputo, Michael P. +4 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Design of a high SNR electronic heart sound sensor based on a MEMS bionic hydrophone
AIP Advances, 2019 Since most of the contact conduction type of heart sound sensors don’t take into account the acoustic signal attenuation problem caused by the heart sound signal transmitting to a sensor whose filling materials’ impedance is different to human soft ...
Haixia Li +9 more
doaj +1 more source
Dynamic Competitive Persuasion
, 2020 We examine a dynamic game of competitive persuasion played between two long-lived sellers over $T \leq \infty$ periods. Each period, each seller provides information via a Blackwell experiment to a single short-lived buyer, who buys from the seller whose
Whitmeyer, Mark
core
, 2018 Dynamic tensor data are becoming prevalent in numerous applications. Existing tensor clustering methods either fail to account for the dynamic nature of the data, or are inapplicable to a general-order tensor.
Li, Lexin, Sun, Will Wei
core +1 more source
From molecular dynamics to Brownian dynamics [PDF]
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2014 Three coarse-grained molecular dynamics (MD) models are investigated with the aim of developing and analysing multi-scale methods which use MD simulations in parts of the computational domain and (less detailed) Brownian dynamics (BD) simulations in the remainder of the domain. The first MD model is formulated in one spatial dimension.
openaire +4 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source