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Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
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Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
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Computer Graphics and Image Processing, 1978
The three major components of dynamic scene analysis, namely segmentation, occlusion and the computation of three-dimensional information from images are discussed in depth. Segmentation refers to the process of determining features of interest, occlusion analysis includes the deriving of changes due to projection perspective, and computation of three ...
J. K. Aggarwal, W. N. Martin
openaire +1 more source
The three major components of dynamic scene analysis, namely segmentation, occlusion and the computation of three-dimensional information from images are discussed in depth. Segmentation refers to the process of determining features of interest, occlusion analysis includes the deriving of changes due to projection perspective, and computation of three ...
J. K. Aggarwal, W. N. Martin
openaire +1 more source
Analysis of Dynamical Recognizers
Neural Computation, 1997Pollack (1991) demonstrated that second-order recurrent neural networks can act as dynamical recognizers for formal languages when trained on positive and negative examples, and observed both phase transitions in learning and interacted function system-like fractal state sets.
Alan D. Blair, Jordan B. Pollack
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Computing in Science & Engineering, 1999
How materials fracture is one of the most fundamental problems in materials science and engineering. Typically, the stress fields near the crack tip are highly nonlinear, and stress-field decay far from the tip is very slow, making fracture a difficult problem.
Priya Vashishta, Aiichiro Nakano
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How materials fracture is one of the most fundamental problems in materials science and engineering. Typically, the stress fields near the crack tip are highly nonlinear, and stress-field decay far from the tip is very slow, making fracture a difficult problem.
Priya Vashishta, Aiichiro Nakano
openaire +1 more source
Dynamics in Epistasis Analysis
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2018Finding regulatory relationships between genes, including the direction and nature of influence between them, is a fundamental challenge in the field of molecular genetics. One classical approach to this problem is epistasis analysis. Broadly speaking, epistasis analysis infers the regulatory relationships between a pair of genes in a genetic pathway ...
Aseel Awdeh +3 more
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2012
In the previous chapters we have examined static extraction of program features for the purpose of birthmark construction. Dynamic analysis is examined in this chapter. It is an alternative approach to static analysis that can be used for birthmark construction. Dynamic analysis concerns itself with analysing a running program. The program being run is
Cesare, S, Xiang, Yang
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In the previous chapters we have examined static extraction of program features for the purpose of birthmark construction. Dynamic analysis is examined in this chapter. It is an alternative approach to static analysis that can be used for birthmark construction. Dynamic analysis concerns itself with analysing a running program. The program being run is
Cesare, S, Xiang, Yang
openaire +1 more source
1997
The standard possible worlds model and its associated Kripke semantics provide an intuitive way of modelling the reasoning processes that an ideal agent may perform on its beliefs. In this paper a way of modelling non-ideal agents (within the possible worlds framework) is considered.
Antonio Moreno, Ton Sales
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The standard possible worlds model and its associated Kripke semantics provide an intuitive way of modelling the reasoning processes that an ideal agent may perform on its beliefs. In this paper a way of modelling non-ideal agents (within the possible worlds framework) is considered.
Antonio Moreno, Ton Sales
openaire +1 more source

