Results 91 to 100 of about 6,033,147 (341)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Influence of different jaw positions on dynamic balance using Y‐balance test

Brain and Behavior, 2019
Jaw sensory‐motor system has been shown to affect static balance of the body. It would be interesting to know whether it can influence dynamic balance as well.
H. Zafar, A. Alghadir, Z. Iqbal, A. Iqbal, S. Anwer, A. Alnahdi   +5 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The effect of blood flow restriction and plyometric training methods on dynamic balance of Taekwondo athletes

Pedagogy of Physical Culture and Sports, 2020
Background and Study Aim. Taekwondo (TKD) is a combat sport emphasizing on kicking techniques and dynamic footwork. Specialized balance ability is crucial for Taekwondo practitioners.
Manolya Akin, İnci Kesilmiş
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Effect of a Six-Week Intervention Using Small-Sided Games (SSG), Ladder Drill, and Dynamic Balance on Agility of Young Futsal Players

Physical Education Theory and Methodology
Objectives. This study aimed to compare the effects of small-sided games (SSG) and ladder drills (LD) on agility performance in futsal players with different levels of dynamic balance (DB), which was examined as a moderating variable.
Ilham Ilham, Raffiandy Alsyifa Putra, Bekir Erhan Orhan, Ardi Nusri, Zulaini Zulaini, Randi Kurniawan, Novadri Ayubi, Vlad Adrian Geantă   +7 more
doaj   +1 more source

Association of Dynamic Balance With Sports-Related Concussion: A Prospective Cohort Study

American Journal of Sports Medicine, 2018
Background: Concussion is one of the most common sports-related injuries, with little understood about the modifiable and nonmodifiable risk factors. Researchers have yet to evaluate the association between modifiable sensorimotor function variables and ...
W. Johnston, M. O'Reilly, C. Duignan, M. Liston, Rod McLoughlin, G. Coughlan, B. Caulfield   +6 more
semanticscholar   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Dynamic Stability Analysis of Progressive Supranuclear Palsy Affected Gait Using Lyapunov Floquet Theory

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Progressive supranuclear palsy (PSP) is a neurodegenerative disease with severe gait and balance deficits. There are no effective ways to assess dynamic balance during walking in PSP.
Sandesh G. Bhat, Farwa Ali, Cecilia A. Hogen, Asghar Rezaei, Keith A. Josephs, Jennifer L. Whitwell, Kenton R. Kaufman   +6 more
doaj   +1 more source

Inertial Sensor Technology Can Capture Changes in Dynamic Balance Control during the Y Balance Test

Digital Biomarkers, 2018
Introduction: The Y Balance Test (YBT) is one of the most commonly utilised clinical dynamic balance assessments. Research has demonstrated the utility of the YBT in identifying balance deficits in individuals following lower limb injury.
W. Johnston, M. O'Reilly, G. Coughlan, B. Caulfield   +3 more
semanticscholar   +1 more source