Results 71 to 80 of about 711,746 (306)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Overview of Dynamic Bond Based Hydrogels for Reversible Adhesion Processes
GelsPolymeric hydrogels are soft materials with a three-dimensional (3D) hydrophilic network capable of retaining and absorbing large amounts of water or biological fluids.
Ilaria Condò +4 more
doaj +1 more source
A Transient Bond Model for Dynamic Constraints in Meso-Scale Coarse-Grained Systems
, 2018 The dynamical properties of entangled polymers originate from the dynamic constraints due to the uncrossability between polymer chains. We propose a highly coarse-grained simulation model with transient bonds for such dynamically constrained systems ...
Uneyama, Takashi
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Improving the energy efficiency of power transmissions of a rolling stock on the basis of dynamic anisotropy of frictional contact [PDF]
E3S Web of Conferences, 2019 The analysis showed the following tendencies of development and energy efficiency of designs of gearboxes for track machines: provision of a maximum level of efficiency, removal of rupture of a stream of the passed capacity, provision of a high level of ...
Shapovalov Vladimir +4 more
doaj +1 more source
Financial innovation and arbitrage in the Spanish bond market [PDF]
, 2001 This paper empirically tests the level of sequential arbitrage in the Spanish bond market. The test is implemented by drawing on default free and option free pure discount and coupon bonds issued by the Spanish government.
Balbás, Alejandro, López, Susana
core +2 more sources
Granular metamaterials with dynamic bond reconfiguration
Science AdvancesBiological materials dynamically reconfigure their underlying structures in response to stimuli, achieving adaptability and multifunctionality. Conversely, mechanical metamaterials have fixed interunit connections that restrict adaptability and reconfiguration.
Zhiqiang Meng, Hujie Yan, Yifan Wang
openaire +3 more sources
Dynamic Causality in Hybrid Bond Graphs
, 2017 Hybrid models are those containing continuous and discontinuous behaviour. In constructing dynamic systems models, it is frequently desirable to abstract rapidly changing, highly nonlinear behaviour to a discontinuity. Bond graphs lend themselves to systems modelling by being multi-disciplinary and reflecting the physics of the system.
Rebecca Margetts, Roger F. Ngwompo
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source