Results 201 to 210 of about 977,786 (269)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Testing Small-Strain Dynamic Characteristics of Expanded Polystyrene Lightweight Soil: Reforming the Teaching of Engineering Detection Experiments. [PDF]

Polymers (Basel)
Jiang P, Wu X, Chen L, Li N, Wu E.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Analysis of the Influence of the Dynamic Characteristics of an Optical Bench on Optical Mechanical System Imaging Under Vibration Conditions. [PDF]

Sensors (Basel)
Wang Y, Jia P, Wang P, Liu Z, Zhang Y, Sun L.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Changes in the dynamic characteristics of G-protein can alter the immune-protection efficacy of rabies virus vaccine. [PDF]

J Virol
Chen C-x, Wang X, Su W, Tian Y, Gao Y, Liu D-l, Xiang H, Liu B-c, Shi J-l, Zhang Y, Shen D, He W-z, Yang L, Hong C, Wu F, Shi L-t, Cun Y-n, Zhou J.   +17 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Numerical Investigation of the Impact of Cracks and Stiffness Loss in the Supporting System for the Dynamic Characteristics of a Rotating Machine. [PDF]

Materials (Basel)
Żywica G, Kiciński J.
europepmc   +1 more source

Aberrant white matter and subcortical gray matter functional network connectivity associated with static and dynamic characteristics in subjects with temporal lobe epilepsy. [PDF]

Front Neurosci
Das SK, Hanna GB, Sun H, Biswal BB.
europepmc   +1 more source

Influence of the driving environment on the dynamic characteristics of a DCT vehicle starting considering the longitudinal and vertical coupling model. [PDF]

Sci Rep
Guo Z, Li A, Feng J, Zheng Y, Qin D, Ge S.   +5 more
europepmc   +1 more source