Results 201 to 210 of about 7,305,148 (249)

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Diagnostic values of diffusion-weighted imaging and dynamic contrast-enhanced MRI in the pathological grading of adenoid cystic carcinoma. [PDF]

BMC Med Imaging
An P, Jiang N, Li J, Li W, Zhou K, Xin J, Jing P, Sun L.   +7 more
europepmc   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Deep learning-based classification of parotid gland tumors: integrating dynamic contrast-enhanced MRI for enhanced diagnostic accuracy. [PDF]

BMC Med Imaging
Sinci KA, Koska IO, Cetinoglu YK, Erdogan N, Koc AM, Eliyatkin NO, Koska C, Candan B.   +7 more
europepmc   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Morphological and Dynamic Contrast-Enhanced MRI Characteristics of Breast Imaging Reporting and Data System (BI-RADS) 3 and Above Breast Masses With Color Doppler and Histopathological Correlation. [PDF]

Cureus
Parashar S, Saxena S, Sharma J, Shukla S.   +3 more
europepmc   +1 more source

Targeted Perturbation of Mitochondrial Energy Metabolism via Thermoelectric Nanoflowers for Enhanced Cuproptosis Echoed With Immunotherapy

Advanced Science, EarlyView.
We fabricated a thermoelectric nanomedicine to disrupt the ATP energy supply for the copper transporter ATP7B, thereby enhancing cuproptosis and achieving synergistic immunotherapy for anti‐tumor purposes. The fabricated TBCT NFs can efficiently disrupt the electron transport chain function via superoxide‐induced NADH oxidation, leading to ATP ...
Haoyang Du, Chao Xu, Hao Wang, Bo Peng, Peng Liu, Wei Gao, Tao Ye, Xinyuan Yu, Ying Shi, Jiaxin Liu, Tiancong Zhao, Bin Sun, Piaoping Yang, Manjie Zhang   +13 more
wiley   +1 more source

Blood-brain barrier dysfunction in cerebral arteriovenous malformations. A murine model of hypoperfusion-reperfusion injury assessed with dynamic contrast-enhanced MRI. [PDF]

Brain Spine
Pedrosa L, Mosteiro A, Codes M, Cabrera G, Aguado L, Planas AM, Amaro S, Martin A, Rodríguez-Hernández A, Torné R.   +9 more
europepmc   +1 more source

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

Advanced Science, EarlyView.
A mitochondrial‐targeted FeCD‐SS31 nanoplatform integrates ROS‐responsive SS31 release with cascade antioxidant Fe3O4/CDs cores to suppress both de novo and existing ROS. By restoring mitochondrial complex integrity and blocking caspase‐1–GSDMD‐N pyroptosis, it reduces neutrophil infiltration and alleviates hepatic ischemia–reperfusion injury, while ...
Qianying Du, Lian Xu, Tingting Xia, Wenli Zhang, Sijin Chen, Xiyue Rong, Ying Luo, Yi Wang, Jia Liu, Yun Liu, Haitao Ran, Dajing Guo, Jie Xu   +12 more
wiley   +1 more source