Results 51 to 60 of about 7,385,916 (287)

Cluster analysis of the signal curves in perfusion DCE-MRI datasets [PDF]

, 2012
Pathological studies show that tumors consist of different sub-regions with more homogeneous vascular properties during their growth. In addition, destroying tumor's blood supply is the target of most cancer therapies.
Mohajer, M., Mohajer, Mojgan
core   +1 more source

Angiogenesis in hematological malignancy – Evaluated by dynamic contrast-enhanced MRI

Journal of Cancer Research and Practice, 2016
Bone marrow angiogenesis can be measured by DCE-MRI. DCE-MRI is an imaging technique that appears to provide quantitative and biologically relevant information related to tumor vasculature and angiogenesis, which can inform novel drug efficacy, monitor ...
Tiffany Ting-Fang Shih
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Could new mammography techniques be an alternative for dynamic contrast-enhanced breast MRI in the diagnosis and preoperative staging of breast lesions?

The Egyptian Journal of Radiology and Nuclear Medicine
Background Breast cancer is the most common malignant tumor among women, and all the imaging modalities are used to help in the early detection and accurate diagnosis of breast abnormalities and so led to proper management. Breast tomosynthesis is one of
Marwa A Haggag, Maha H Helal, Rasha M Kamal, Radwa E Mostafa, Asmaa I. Salama, Ahmed E Hassan   +5 more
doaj   +1 more source

Analysis of DCE-MRI Data using a Nonnegative Elastic Net [PDF]

, 2010
We present a nonnegative Elastic Net approach for the analysis of Dynamic Contrast-Enhanced Magnetic Resonance Imaging data. A multi-compartment approach is considered, which is translated into a (restricted) least square model selection problem.
Gertheiss, Jan, Kärcher, Julia C., Schmid, Volker J.   +2 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

The value of dynamic contrast-enhanced MRI in the diagnosis and management of triple-negative breast cancer

The Egyptian Journal of Radiology and Nuclear Medicine, 2020
Background Breast cancer is undoubtedly the world’s most frequent cancer among women. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that does not express estrogen, progesterone, or human epidermal growth factor receptors, yet its ...
Heba Azzam, Rasha Kamal, Hany El-Assaly, Liza Omer   +3 more
doaj   +1 more source

On the Detection of Regions-of-Interest in Dynamic Contrast-Enhanced MRI [PDF]

, 2007
Multivariate imaging technologies such as Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) have recently gained an important attention as it improves tumour detection. Modelling of contrast media uptake and washout kinetic parameters which are closely related to physiological and anatomical features helps to diagnose and detect a possible
David Raba, Marta Peracaula, Robert Marti, Joan Martí   +3 more
openaire   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source