Results 31 to 40 of about 3,436,106 (248)

Dynamic multiphase semi-crystalline polymers based on thermally reversible pyrazole-urea bonds

open access: yesNature Communications, 2019
Dynamic polymer materials with reversible covalent bonds can reorganize their macromolecular architectures, and thus produce a macroscopic response to the environment.
Wen-Xing Liu   +6 more
doaj   +1 more source

Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system

open access: yesJournal of Pharmaceutical Analysis, 2022
A mixed drug self-delivery system (DSDS) with high drug content (>50%) was developed to regulate pH-triggered drug release, based on two doxorubicin (DOX)-DOX dimmers: D-DOXADH and D-DOXcar conjugated with acid-labile dynamic covalent bonds (hydrazone ...
Jiagen Li   +3 more
doaj   +1 more source

Strong self-healing close-loop recyclable vitrimers via complementary dynamic covalent/non-covalent bonding [PDF]

open access: yes
Epoxy vitrimers represent a new class of high-performance sustainable resins because of their desired mechanical and thermally malleable properties. Unfortunately, existing epoxy vitrimers cannot self-heal at room temperature (R.T.) due to the trade-off ...
Zhang, Qi   +8 more
core   +1 more source

From Simplicity to Complexity via Subcomponent Self-Assembly

open access: yesCHIMIA, 2008
Subcomponent self-assembly allows the construction of complex architectures from simple building blocks via the formation of covalent bonds around metal templates.
Marie Hutin   +2 more
doaj   +1 more source

Surface‐Enforced Alignment of Reprogrammable Liquid Crystalline Elastomers

open access: yesAdvanced Science, 2022
Liquid crystalline elastomers (LCEs) are stimuli‐responsive materials capable of undergoing large deformations. The thermomechanical response of LCEs is attributable to the coupling of polymer network properties and disruption of order between liquid ...
Tayler S. Hebner   +4 more
doaj   +1 more source

Mechanically Resistant Poly(N‐vinylcaprolactam) Microgels with Sacrificial Supramolecular Catechin Hydrogen Bonds

open access: yesAdvanced Science, 2022
Microgels (μgels) swiftly undergo structural and functional degradation when they are exposed to shear forces, which potentially limit their applicability in, e.g., biomedicine and engineering.
Emilia Izak‐Nau   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Covalent adaptable networks using boronate linkages by incorporating TetraAzaADamantanes

open access: yesFrontiers in Chemistry, 2023
Boronic esters prepared by condensation of boronic acids and diols have been widely used as dynamic covalent bonds in the synthesis of both discrete assemblies and polymer networks.
Simon van Hurne   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

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