Results 61 to 70 of about 5,322,978 (245)
Switching between Non-isoenergetic Dynamic Covalent Re-actions using Host-guest Chemistry [PDF]
CO2 reacts with simple amines in presence of water to generate dynamic combinatorial libraries of majority (i.e., am-monium carbamates) and minority (i.e., ammonium carbonates) non-isoenergetic covalent adducts.
Florent, Perret +8 more
core +2 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
A facile route to old and new cyclophanes via self-assembly and capture
Nature Communications, 2016 Cyclophanes—consisting of aromatic rings formed into a macrocycle—can display interesting properties but are challenging targets for synthesis. Here, the authors report a route to form cyclophanes by dynamic covalent chemistry, forming disulfides that ...
Mary S. Collins +4 more
doaj +1 more source
EcoMat, 2023 Dynamic covalent chemistry offers a solution to tackle the recycling issue of epoxy resins (EPs) and their carbon fiber‐reinforced composites; however, the vulnerability to creep associated with the inflammable nature of the EPs are the key obstacles for
Song Gu +7 more
doaj +1 more source
Large-Scale Synthesis of Covalent Organic Frameworks: Challenges and Opportunities
Membranes, 2023 Connecting organic building blocks by covalent bonds to design porous crystalline networks has led to covalent organic frameworks (COFs), consequently transferring the flexibility of dynamic linkages from discrete architectures to extended structures. By
Harsh Vardhan +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Supramolecular motifs in dynamic covalent PEG-hemiaminal organogels [PDF]
, 2015 Dynamic covalent materials are stable materials that possess reversible behaviour triggered by stimuli such as light, redox conditions or temperature; whereas supramolecular crosslinks depend on the equilibrium constant and relative concentrations of ...
Ter Huurne, G.M. +8 more
core +2 more sources
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Assembled molecular face-rotating polyhedra to transfer chirality from two to three dimensions
Nature Communications, 2016 Protein subunits on the capsids of icosahedral viruses can form patterns with rotational symmetry, which are difficult to recreate in the laboratory. Here the authors report a strategy to construct 3D chiral polyhedra with rotational faces from 2D chiral
Xinchang Wang +10 more
doaj +1 more source
Covalent adaptable networks using boronate linkages by incorporating TetraAzaADamantanes
Frontiers in Chemistry, 2023 Boronic esters prepared by condensation of boronic acids and diols have been widely used as dynamic covalent bonds in the synthesis of both discrete assemblies and polymer networks.
Simon van Hurne +2 more
doaj +1 more source