Results 31 to 40 of about 58,968 (211)

Exploratory Vulnerability Assessment of the Urban Ecological Security Pattern in Bogotá: Static and Dynamic Attack Simulations and Cascading-Failure Modelling in a Global South City

ISPRS International Journal of Geo-Information
The Ecological Security Pattern (ESP), composed of ecological sources, resistance surfaces, and corridors, provides a spatial basis for mitigating urban landscape fragmentation and sustaining ecological security.
Jose David Martinez Otalora, Jie Shen, Anyela Piedad Rojas Celis   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Ecological flow-driven multifunctionality: A Nature-based Solutions framework for urban ecological corridor planning in high-density cities

Ecological Indicators
This study develops an ecological flow driven framework, grounded in Nature-based Solutions (NbS), that upgrades the canonical source, resistance, and path paradigm for urban ecological corridors to the realities of high-density cities.
Lang Zhang, Haoran Yu, Qicheng Zhong, Guilian Zhang, Zhuqing Wang, Qingping Zhang   +5 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Urban flood disaster risk management using multi-criteria decision-making methods: A scoping review

International Journal of Strategic Property Management
Statistical data indicates a rising trend in the frequency and unpredictability of floods globally. Regions traditionally less affected by flooding are reportedly experiencing an increased impact, underscoring the widespread nature of this phenomenon ...
Gintarė Piaseckienė, Jurgita Antuchevičienė   +1 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Mapping the vulnerable: A framework for analyzing urban social vulnerability and its societal impact

Societal Impacts
Widespread high exposure and vulnerability, coupled with inadequate adaptive capacity, underscore the urgent need for targeted interventions and policies to enhance urban resilience.
Subham Roy, Suranjan Majumder, Arghadeep Bose, Indrajit Roy Chowdhury   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

GIS-Based Framework for Integrating Urban Heritage and Lighting Planning

Buildings
This study develops a GIS-based, heritage-sensitive urban lighting framework for Niğde, Türkiye, integrating Sentinel-2 MSI Level-2A imagery (10 m), ASTER DEM, and municipal cadastral data.
Orhun Soydan, Mertkan Fahrettin Tekinalp
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source