Results 61 to 70 of about 455,930 (238)

Improving the efficacy of the lean index through the quantification of qualitative lean metrics [PDF]

, 2015
Multiple lean metrics representing performance for various aspects of lean can be consolidated into one holistic measure for lean, called the lean index, of which there are two types.
Oleghe, Omogbai, Salonitis, Konstantinos
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Postural instability in the digital age: A scoping review of screen exposure and balance outcomes in community-dwelling older adults

Archives of Gerontology and Geriatrics Plus
Background: Digital screen use is increasingly common among older adults, yet its implications for balance and postural control are not well defined. Age-related sensory, vestibular and cognitive changes may increase vulnerability to balance disturbances
Tamanna Sharma, BPT, (MPT), Nidhi Sharma, BPT, MPT, PhD, Simranjeet Kaur, BPT, MPT, Parveen Kumar, BPT, MPT, Preeti Kapri, BPT, MPT   +4 more
doaj   +1 more source

The assessment of naturalness and its role for nature conservation and forestry in Europe [PDF]

, 2008
Naturalness is one of the most important criteria in nature conservation. This paper examines the fundamental concepts underlying the definition and assessment of naturalness.
Reif, Albert, Walentowski, Helge
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: a phase I trial of bortezomib plus bevacizumab. [PDF]

, 2014
PurposeWe hypothesized that bortezomib, an agent that suppresses HIF-1α transcriptional activity, when combined with bevacizumab, would obviate the HIF-1α resistance pathway.
Amin, Hesham M, Angelo, Laura S, Falchook, Gerald S, Hess, Kenneth, Hong, David, Howard, Adrienne N, Huang, Mei, Jackson, Edward F, Janku, Filip, Kurzrock, Razelle, Lawhorn, Kristie N, Naing, Aung, Ng, Chaan S, Parkhurst, Kristin L, Tannir, Nizar M, Vishwamitra, Deeksha, Wheler, Jennifer J   +16 more
core   +2 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Epigenetic regulation of inflammation in post-operative organ dysfunction: A scoping review protocol.

PLoS ONE
IntroductionThe inflammatory response to surgery is complex, dynamic and exhibits variability in magnitude and duration among patients undergoing similar operations.
Ruairí Wilson, Charlotte Fern, Carl Goodyear, Ben Shelley   +3 more
doaj   +1 more source

Postural control imbalance in individuals with a minor lower extremity amputation: a scoping review protocol. [version 2; peer review: 2 approved]

F1000Research
Introduction Lower extremity amputations (LEA) impact the quality of life and physical abilities and increase the risk of developing secondary complications.
Gabriel Moisan, Virginie Blanchette, Ahmed Dami, Maxime Acien   +3 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source