Results 41 to 50 of about 216,212 (263)
Dynamic disorder in quasi-equilibrium enzymatic systems. [PDF]
PLoS ONE, 2010 Conformations and catalytic rates of enzymes fluctuate over a wide range of timescales. Despite these fluctuations, there exist some limiting cases in which the enzymatic catalytic rate follows the macroscopic rate equation such as the Michaelis-Menten ...
Srabanti Chaudhury, Oleg A Igoshin
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Actuators, 2021 Dynamic modeling of soft pneumatic actuators are a challenging research field. In this paper, a dynamic modeling method used for a bi-directionaly soft pneumatic actuator with symmetrical chambers is proposed.
Yiqing Li, Wen Zhou, Junwu Wu, Guoxu Hu
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Equilibrium Cycle: A “Dynamic” Equilibrium
In this paper, we introduce a novel equilibrium concept, called the equilibrium cycle, which seeks to capture the outcome of oscillatory game dynamics. Unlike the (pure) Nash equilibrium, which defines a fixed point of mutual best responses, an equilibrium cycle is a set-valued solution concept that can be demonstrated even in games where best ...
Walunj, Tushar Shankar +3 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
General Equilibrium and Dynamic Inconsistency
SSRN Electronic Journal, 2022 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kirill Borissov +2 more
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Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Вестник КазНУ. Серия математика, механика, информатика, 2016 In this paper the technique of analytical determination of internal forces in links of planar mechanisms and manipulators with statically indeterminate structures taking into account the distributed dynamical loads, a dead weight and the operating ...
S. Zhilkibayeva +2 more
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Equilibrium Sampling From Nonequilibrium Dynamics [PDF]
Journal of Statistical Physics, 2006 We present some applications of an Interacting Particle System (IPS) methodology to the field of Molecular Dynamics. This IPS method allows several simulations of a switched random process to keep closer to equilibrium at each time, thanks to a selection mechanism based on the relative virtual work induced on the system.
Rousset, Mathias, Stoltz, Gabriel
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source