Results 101 to 110 of about 3,277,763 (307)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

State Space Reduction for Dynamic Process Creation [PDF]

Scientific Annals of Computer Science, 2010
Automated verification of dynamic multi-threaded computing systems is severely affected by problems relating to dynamic process creation. In this paper, we describe an abstraction technique aimed at generating reduced state space representations for such
H. Klaudel, M. Koutny, E. Pelz, F. Pommereau   +3 more
doaj  

Translation for The Readers: an Analysis on The Translation of Sean Coveys The 7Th Habits of Highly Effective TeenS

LLT Journal: A Journal on Language and Language Teaching, 2017
A good translation should be parallel with the source text both in form andin meaning. Yet, because of the uniqueness of each language, parallel in form is oftendifficult to achieve.
Carla Sih Prabandari
doaj   +1 more source

Equivalence of dynamical ensembles and Navier-Stokes equations [PDF]

Physics Letters A, 1996
A reversible version of the Navier Stokes equation is studied. A conjecture emerges stating the equivalence between the reversible equation and the usual Navier Stokes equation. The latter appears as a statement of ensembles equivalence in the limit of infinite Reynolds number, which plays the role of the thermodynamic limit.
openaire   +3 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

ANALYSIS ON THE TRANSLATION OF MOVIE VCD SYNOPSES BASED ON THE DYNAMIC EQUIVALENCE TRANSLATION THEORY [PDF]

, 2006
ANALYSIS ON THE TRANSLATION OF MOVIE VCD SYNOPSES BASED ON THE DYNAMIC EQUIVALENCE TRANSLATION ...
WIRWIDYA HENDRA, WIWIN
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Transparency in the Netflix Series Baitu Tahir Subtitles and Its Implications for Dynamic Equivalence

Jurnal Al Bayan: Jurnal Jurusan Pendidikan Bahasa Arab
This article presented the subtitles transparency from the Netflix series Baitu Tahir. Additionally, the implications of transparency were illustrated on dynamic equivalence.
Alfina Robi'ah Adawiyah, Arief Ma'nawi, Sajarwa Sajarwa, Ahmad Syafran, Dinda Sekar Octavianti, David Ginola   +5 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source