Results 101 to 110 of about 12,139,664 (308)

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Impact Strategy Development: Questions Bank and Interview Guide

open access: yes
The tool ‘Impact Strategy Development: Questions Bank and Interview Guide’ consists of (1) a three step interview guide and (2) an Excel file with a questions bank to use and tailor for your interviews or other methods for engaging with your community ...
Evaluating Societal Impact
core   +1 more source

An Investigation into the Design and Analysis of the Front Frame Bumper with Dynamic Load Impact

open access: yesEngineering Proceedings
The present study is aimed at upgrading the passenger car’s front inner bumper. The dynamic explicit time-stepping method IMPACT was used to conduct the impact analysis.
B. Gowthama Rajan   +6 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Experimental study on dynamic mechanical properties and damage law of steel fiber concrete

open access: yes工程科学学报
Investigating the effect of steel fiber blending schemes on the dynamic mechanical properties and damage evolution of concrete is crucial for deep-shaft construction projects.
Yisong YU   +4 more
doaj   +1 more source

ESTIMATION OF THE RESISTANCE OF A THREE-LAYERED STRUCTURE WITH A PYRAMID DISCONTINUOUS FILLER TO DYNAMIC STRESS USING THE FINITE ELEMENT METHOD

open access: yesВестник Дагестанского государственного технического университета: Технические науки, 2019
Objectives. In this research, we set out to explore the possibility of increasing the resistance of three-layered panels with a pyramid filler filled with fibrous material to dynamic loads.
O. M. Ustarkhanov   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Thinking About my Impact and Engagement: A Worksheet

open access: yes
What does making positive societal impact mean to you? How do you map current and potential partners and beneficiaries? How to align your work to their needs? This workshop package offers a brief printable worksheet with accompanying presentation slides,
Evaluating Societal Impact
core   +1 more source

Oscillations of First Order Delay Dynamic Equations

open access: yes, 2006
Stavroulakis, Ioannis/0000-0002-4810-0540Consider the first order linear delay dynamic equation of the forms x(Delta)(t) + p(t)x(tau(t)) = 0. (E) New oscillation criteria are established which contain well-known criteria for delay differential and ...
Sahiner, Y., Stavroulakis, I. P.
core   +1 more source

Experimental Study on Directional Rock Fracture by Energy-Gathering Cutting under Dynamic Impact

open access: yesGaoya wuli xuebao
This study addresses the challenge of excavating through heterogeneous tuffaceous sandstone formations in tunnel construction by proposing a novel energy-gathering slotting rock-breaking technique based on dynamic impact.
Wei WANG   +5 more
doaj   +1 more source

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