Results 41 to 50 of about 5,655,620 (210)

Physiological and clinical consequences of relief of right ventricular outflow tract obstruction late after repair of congenital heart defects. [PDF]

, 2006
BACKGROUND: Right ventricular outflow tract obstruction (RVOTO) is a common problem after repair of congenital heart disease. Percutaneous pulmonary valve implantation (PPVI) can treat this condition without consequent pulmonary regurgitation or ...
Sridharan, S, Schievano, S, Coats, L, Jones, R, Mist, B, Taylor, AM, Deanfield, JE, Bonhoeffer, P, Derrick, G, Khambadkone, S, Pellerin, D   +10 more
core  

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Pacing to treat low cardiac output syndrome following elective aortic valve replacement

Saudi Journal of Anaesthesia, 2012
We report a case of low cardiac output syndrome caused by dynamic left ventricular (LV) outflow obstruction after aortic valve replacement (AVR). This recognized phenomenon probably occurs more frequently than appreciated, and the author suggests that ...
Muhammad Ishaq
doaj   +1 more source

Coincidence of Events Causing Paradoxical Hypotension in a Patient with an Intra-Aortic Balloon Pump

European Journal of Case Reports in Internal Medicine, 2022
The left ventricular outflow tract is a region of the left ventricle that lies between the anterior leaflet of the mitral valve and the ventricular septum.
Muhammad Atif Masood Noori, Hardik Fichadiya, Hasham Saeed, Qirat Jawed, Shruti Jesani, Asnia Latif, Meherwan Joshi   +6 more
doaj   +1 more source

Dynamic left ventricular obstruction evoked by exercise: importance of outflow tract size [PDF]

European Journal of Echocardiography, 2009
We have read with interest the article by Zywica et al. 1 recently published in an issue of the European journal of Echocardiography. The authors analysed, in 300 patients referred for exercise echocardiography, the prevalence and predictive factors of dynamic left ventricular outflow tract obstruction on immediate post-exercise echocardiographic ...
Fernando, Cabrera-Bueno, Maria Jose, Molina-Mora, Manuel, Jimenez-Navarro, Jose Manuel, Garcia-Pinilla, Eduardo, de Teresa Galvan   +4 more
openaire   +2 more sources

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Subvalvular aortic stenosis associated with dynamic outflow tract obstruction: A case report [PDF]

, 1976
Hemodynamic and angiographic findings are described in a 27-year-old patient, who had undergone surgical operation for subvalvular membranous aortic stenosis.
Madrazo, Armando Cesar, Torbey, Peter, Drake, Ellet H., Khaja, Fareed, Karo, James J., Goldstein, Sidney, Anbe, Daniel T.   +6 more
core   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Hypertrophic cardiomyopathy: Part 1 - Introduction, pathology and pathophysiology

Annals of Cardiac Anaesthesia, 2014
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease with many genotype and phenotype variations. Earlier terminologies, hypertrophic obstructive cardiomyopathy and idiopathic hypertrophic sub-aortic stenosis are no longer ...
Praveen Kerala Varma, Praveen Kumar Neema   +1 more
doaj   +1 more source